ID   W9S274_9ROSA            Unreviewed;       848 AA.
AC   W9S274;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=L484_025223 {ECO:0000313|EMBL:EXC10642.1};
OS   Morus notabilis.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Moraceae; Moreae; Morus.
OX   NCBI_TaxID=981085 {ECO:0000313|EMBL:EXC10642.1, ECO:0000313|Proteomes:UP000030645};
RN   [1] {ECO:0000313|Proteomes:UP000030645}
RP   NUCLEOTIDE SEQUENCE.
RA   He N., Zhao S.;
RT   "Draft Genome Sequence of a Mulberry Tree, Morus notabilis C.K. Schneid.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as an E3 ubiquitin ligase.
CC       {ECO:0000256|ARBA:ARBA00003861}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; KE345646; EXC10642.1; -; Genomic_DNA.
DR   RefSeq; XP_010106466.1; XM_010108164.1.
DR   AlphaFoldDB; W9S274; -.
DR   STRING; 981085.W9S274; -.
DR   GeneID; 21407930; -.
DR   KEGG; mnt:21407930; -.
DR   eggNOG; ENOG502QVJF; Eukaryota.
DR   OrthoDB; 370121at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000030645; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd16655; RING-Ubox_WDSUB1-like; 1.
DR   CDD; cd01989; STK_N; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR45647; OS02G0152300 PROTEIN; 1.
DR   PANTHER; PTHR45647:SF43; OS10G0100500 PROTEIN; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF04564; U-box; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030645}.
FT   DOMAIN          506..770
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          777..848
FT                   /note="U-box"
FT                   /evidence="ECO:0000259|PROSITE:PS51698"
FT   REGION          293..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          352..449
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        293..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   848 AA;  94968 MW;  5C1A8C5932903046 CRC64;
     MELLRPSSPP THAHSPVSLY GFSFPATSRR GLDRAGTSQL PEIVEEEGNN NKVHVALGKS
     EEKAMSLLNW TFRRFQGKEI CILHVHLPSQ LIPTLLGNLP ATQASAEVVS TYRKFEKEQM
     SKLLQRYSNF CSRAKVNASI ITIEAEQVQK GIVDLVNENG IRKLVMGAVP ENCMKVKKGS
     SKANYAAKKA PLFCEIWFIH KGKHVWTRDT PEDPSSLPSC SLPQIATAEN SRSRSFQYGK
     NKSIHPDCLQ SKSAKSAVCT QISNRVQYEP VHAELASSPT LSRSACTCLH DLNDSSSTTS
     SSSCSGYNSA ERRGLSDSDL KVGEERLYSQ LIQATIEAET SSNEACADSL KVKKLELEAR
     EAISKVKAFE SALACEGQLR KEAEEALRTT LEEQEKLLEE RDDITQELHR TMRNVALLDS
     RAQEANRRHD EAVGELKLVQ ESIATLRQEK QRIRRPKIEA LRWLERWRSH GQGGATNYDG
     LVGSVKELHE LAEFSLPDLQ TATCNFSESF ILCQEGYGYV YKGEMMGRTV AIRKLYPYNM
     QGESEFQQEV KVLGKLQHPH LVTLLGVCPE AWSLVYEYLP NGGLQNHLFR KSNVLTWEIR
     VRIIAEIASA LCFLHSSKPE KIVHGDLTPR KILLDSELRC KICDFGICRS ITEDNLQCPS
     LRWNTGPKGS FYYTDPEFQR IGILTPKSDA YSFGLIVLQL LTRRSPVGLA GEVRKAVSSG
     KLASILDSSA GEWPMLVARR LADIGLQCCK LNSRDRPDLT PSLVRELEQL HDSEERPVPS
     FFLCPILQEI MHDPQVAADG FTYEGEAMRG WLQNGKETSP MTNLKLSHLN LTPNHAIRLA
     IQDWLCKA
//