ID W9SC32_9ROSA Unreviewed; 336 AA.
AC W9SC32;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Flavanone 4-reductase {ECO:0000256|ARBA:ARBA00042087};
DE EC=1.1.1.219 {ECO:0000256|ARBA:ARBA00039057};
DE EC=1.1.1.234 {ECO:0000256|ARBA:ARBA00039055};
GN ORFNames=L484_021942 {ECO:0000313|EMBL:EXC25070.1};
OS Morus notabilis.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Moraceae; Moreae; Morus.
OX NCBI_TaxID=981085 {ECO:0000313|EMBL:EXC25070.1, ECO:0000313|Proteomes:UP000030645};
RN [1] {ECO:0000313|Proteomes:UP000030645}
RP NUCLEOTIDE SEQUENCE.
RA He N., Zhao S.;
RT "Draft Genome Sequence of a Mulberry Tree, Morus notabilis C.K. Schneid.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH;
CC Xref=Rhea:RHEA:11228, ChEBI:CHEBI:15378, ChEBI:CHEBI:15605,
CC ChEBI:CHEBI:15606, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.234; Evidence={ECO:0000256|ARBA:ARBA00036737};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-
CC dihydroflavonol + H(+) + NADPH; Xref=Rhea:RHEA:54444,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:138176, ChEBI:CHEBI:138188; EC=1.1.1.219;
CC Evidence={ECO:0000256|ARBA:ARBA00036368};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; KE346040; EXC25070.1; -; Genomic_DNA.
DR RefSeq; XP_010110052.1; XM_010111750.1.
DR AlphaFoldDB; W9SC32; -.
DR STRING; 981085.W9SC32; -.
DR GeneID; 21404779; -.
DR KEGG; mnt:21404779; -.
DR eggNOG; KOG1502; Eukaryota.
DR OrthoDB; 1694166at2759; -.
DR Proteomes; UP000030645; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd08958; FR_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF613; DIHYDROFLAVONOL 4-REDUCTASE; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Flavonoid biosynthesis {ECO:0000256|ARBA:ARBA00023241};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030645}.
FT DOMAIN 8..247
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 336 AA; 37668 MW; E0EA97F67EBB7847 CRC64;
MGSKVETVCV TGASGYIGSW LVMRLLERDY TVRATVRDPA NVKKVRHLLE LPKAKSNLTL
WKADLADEGS FNEAIKGCTG VFHVATPMDF DSKDPENEVI KPAIAGILDI MKACLDAKVK
RLVFTSSAGA VDAGPQGRSF YDESYWSDVE FCRTVKMIGW MYFVSKTLAE QAAWKFAKEH
NMDFITIIPT LVIGPFLGPT APSSIITGIA PIIGNEAHYF ILKQGKYIHL DDLCEAHIFL
YEHPKAEGRY ITSSHSATIY ELVKLLKEKY PQYNIPTKFK GFEENIENVE FSSRKLKELG
FQYKYSLEDM FVGAIETCRE KGLLPLAHEN NPNGSD
//
