ID   W9XEA4_9EURO            Unreviewed;       609 AA.
AC   W9XEA4;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:EXJ75291.1};
GN   ORFNames=A1O5_01987 {ECO:0000313|EMBL:EXJ75291.1};
OS   Cladophialophora psammophila CBS 110553.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Cladophialophora.
OX   NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ75291.1, ECO:0000313|Proteomes:UP000019471};
RN   [1] {ECO:0000313|EMBL:EXJ75291.1, ECO:0000313|Proteomes:UP000019471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ75291.1,
RC   ECO:0000313|Proteomes:UP000019471};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXJ75291.1}.
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DR   EMBL; AMGX01000002; EXJ75291.1; -; Genomic_DNA.
DR   RefSeq; XP_007740793.1; XM_007742603.1.
DR   AlphaFoldDB; W9XEA4; -.
DR   STRING; 1182543.W9XEA4; -.
DR   GeneID; 19186720; -.
DR   eggNOG; KOG2304; Eukaryota.
DR   HOGENOM; CLU_031652_0_0_1; -.
DR   OrthoDB; 4517707at2759; -.
DR   Proteomes; UP000019471; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF10; DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10070)-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SMART; SM00135; LY; 2.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000019471}.
FT   DOMAIN          13..170
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          189..282
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   609 AA;  67065 MW;  6C980CF166D656D4 CRC64;
     MWNPPKNYEH RPVAVLGGGV LGRRIACCWA AAGYNVTVRD PGAQQRKDAV DYVTQNAQQY
     AELTGKTPGT IQAFADLDPA VKDAWIVFEA VPESLHLKIE TFALLQKLAP ADCILASNSS
     SYKSSEMLDK VDQDTKLRIL NTHYFMPPDN RLVELMTDGH THPEILQFLA ARHREAALIP
     FIARKESTGF IFNRVWAAIK REVLTILAEG VSTPEEIDNM WNLFWGSKIS PCRMMDQVGL
     DTVTLIEQHY VHERGLPSEK TVGFLEENYL KHGKLGNKCS KGGLYPPTPQ GISDGGIVLL
     DLGIPSSLKG IPSPRDIGGK GRLLKLSKDG KNVKTLVSGA GFPDGIALNS LDGRLYYTDM
     GTFGSNDGRV LSCDLDGNDL QVIIPRGGVH TPKQIAIDEL AGKLYISDRE GLRVVRVSLD
     GSNFEVIVQT GVWENPEEQA DQTKWCVGMT VVPKLGKFFW TQKGPPKSGK GRILSANIDM
     PTAQSPAHRA DVRVIFDKLP EPIDLEYDEE LNSLFWTDRG EIPFGNSLNR SQLSAVGETV
     NGGYARFPKH EIIARNFHEA IGLKLDRKNN AIFVADLGGT LWKTDFNGAN KVKVYEDNAG
     TFTGITLLP
//