ID W9XGW3_9EURO Unreviewed; 482 AA.
AC W9XGW3;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Aldehyde dehydrogenase (NAD+) {ECO:0000313|EMBL:EXJ79757.1};
GN ORFNames=A1O3_08040 {ECO:0000313|EMBL:EXJ79757.1};
OS Capronia epimyces CBS 606.96.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX NCBI_TaxID=1182542 {ECO:0000313|EMBL:EXJ79757.1, ECO:0000313|Proteomes:UP000019478};
RN [1] {ECO:0000313|EMBL:EXJ79757.1, ECO:0000313|Proteomes:UP000019478}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 606.96 {ECO:0000313|EMBL:EXJ79757.1,
RC ECO:0000313|Proteomes:UP000019478};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia epimyces CBS 606.96.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ79757.1}.
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DR EMBL; AMGY01000007; EXJ79757.1; -; Genomic_DNA.
DR RefSeq; XP_007736331.1; XM_007738141.1.
DR AlphaFoldDB; W9XGW3; -.
DR STRING; 1182542.W9XGW3; -.
DR GeneID; 19172131; -.
DR eggNOG; KOG2450; Eukaryota.
DR HOGENOM; CLU_005391_0_2_1; -.
DR OrthoDB; 216092at2759; -.
DR Proteomes; UP000019478; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07106; ALDH_AldA-AAD23400; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044086; LUC3-like.
DR PANTHER; PTHR11699:SF263; ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000019478}.
FT DOMAIN 27..473
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 27..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 482 AA; 52361 MW; B0125C2FFA201D78 CRC64;
MGSIGASLDL FSGFYNTING KLTTTEKTRH GINPANGKPN PEVPVSTPKD VDDAVAAAKE
AFKSWSKTSN EERKKAVLAF ADALERYESD FGKLLTQEQG KPLQFAVGEI KAGVHWLRSL
SKLELKEETI EEDEEKRVVV RHTPLGVTVG IVPWNFPVQL AVGKIAPSVL TGNPIIIKPS
PFTPYCDLKL GELAQQYFPP GVVQVLSGDD NLGPWLTAHP GPDKISFTGS TVTGKKVMES
AAKTLKRVTL ELGGKDPAII TKNINIDAVA QKIGALAFAN SGQVCLAIKR IYVHESIHDK
FRDAIVAFTK TLKVGDGTEE GVTHGPLQNS MQYEKVKTFF SDIEKEKWTV AVGGKNEDKP
GYFITPTIID KPADDSRIAT EEPFGPIVPL LTWSDEDDVI ARANNTKLGL GASVWSDDLD
EATRIARQLD AGSVWVNTHL ELDPNAPFGG HKESGIGYEW GIGGLKAFTN IQTLYLKKKT
SA
//
