ID W9Y2W6_9EURO Unreviewed; 476 AA.
AC W9Y2W6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NAD-dependent aldehyde dehydrogenase {ECO:0000313|EMBL:EXJ76814.1};
GN ORFNames=A1O5_01322 {ECO:0000313|EMBL:EXJ76814.1};
OS Cladophialophora psammophila CBS 110553.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ76814.1, ECO:0000313|Proteomes:UP000019471};
RN [1] {ECO:0000313|EMBL:EXJ76814.1, ECO:0000313|Proteomes:UP000019471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ76814.1,
RC ECO:0000313|Proteomes:UP000019471};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ76814.1}.
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DR EMBL; AMGX01000001; EXJ76814.1; -; Genomic_DNA.
DR RefSeq; XP_007740131.1; XM_007741941.1.
DR AlphaFoldDB; W9Y2W6; -.
DR STRING; 1182543.W9Y2W6; -.
DR GeneID; 19186058; -.
DR eggNOG; KOG2450; Eukaryota.
DR HOGENOM; CLU_005391_1_0_1; -.
DR OrthoDB; 178592at2759; -.
DR Proteomes; UP000019471; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07102; ALDH_EDX86601; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000019471};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 131..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..468
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 476 AA; 51924 MW; EB08BB6507226061 CRC64;
MVAEIITTIS PTTNEPILTR HGKSPEEILR LGTTAQSAFK SYRKSHPSLE SRQQIISKAL
NLLLERQDAL ARELTEQMGR PISYTAKEIT TAVKRAEYMI RVAPEVLERD ATIPGEQEQG
FKRYITRKEP VGVVLVIFAW NYPYLILVNS LIPALLAGCA VILKPSPQTP TIVEHIVDIF
DAAGLPQKVI QYLHCGSPTD LKPLILSPEV NHICFTGSVA AGIAIQTLAA SRVSCSVGLE
LGGKDPAYIR PDVDAAWAAE EIVDGAIFNS GQSCCAIERV YVHADIYDSF LKEVKKVLEG
YRVGDPLEKS THVGPVVSKR SKEAIEKQVA DAIAAGAVDQ TPHNESFKSP AGPKAGNWVA
PVLLTNVNHN MSIMRDETFG PVIPLQKVSG DEEAIALMND SQFGLTASIW TKDTPKGEEL
CGLVQAGTVF VNRADFPSPD LAWTGWKDSG RGVTLSKLAF EQFVKVKSFH VKNYPK
//
