ID W9ZUW9_FUSOX Unreviewed; 704 AA.
AC W9ZUW9;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Thimet oligopeptidase {ECO:0000313|EMBL:EXK32098.1};
GN ORFNames=FOMG_12413 {ECO:0000313|EMBL:EXK32098.1};
OS Fusarium oxysporum f. sp. melonis 26406.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1089452 {ECO:0000313|EMBL:EXK32098.1};
RN [1] {ECO:0000313|EMBL:EXK32098.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=26406 {ECO:0000313|EMBL:EXK32098.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum melonis.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXK32098.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=26406 {ECO:0000313|EMBL:EXK32098.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum f. sp. melonis
RT 26406.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR EMBL; JH659338; EXK32098.1; -; Genomic_DNA.
DR EMBL; JH659338; EXK32099.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:FOMG_12413; -.
DR HOGENOM; CLU_001805_1_1_1; -.
DR Proteomes; UP000030703; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06455; M3A_TOP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR024080; Neurolysin/TOP_N.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 226..699
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 704 AA; 80013 MW; DB8907A43F1F2019 CRC64;
MAPDKYRNPP QAPPLFTATP ESIAADTKKL CDATKNVLDS VTANVTADKA SFANVLEPIL
IDENLAATQR RILTFYHHVS TNKELRDAST EAESAFNDFG IECNMREDVF NAVDAAYANR
ASQDLTKEQA HVLEKERQKY IRNGLRLPAG PKRDRFKEIQ KRLSELEIKA QKNLNEEKGA
IWFTPEELKG VPSDDIDIDS LEKGTGENEG KVKLSFKYNH YFPLIKYAID ADTRRKYTIA
ESNKANVNVP IFQEIITLRD EAARLLGYDN HAALRIEEKM AKTPAAVRTF LDDLRNRLAE
GGAKEINALK EYKKKDYEER GLSFDDSFYM WDTSFYSRIQ KEKEYSVDEA AISQYFPVES
TFAGMLKIFE EIFGFVFVEL KPEERARLSP TGKAEDIVWH EDVLIYSVWD DEASGSSFNG
YLYLDLHPRD NKYGHNANFN LEPGYVTEDG KKHYPVTALV CNFSKPTPKK PSLLKHHEVV
TLFHELGHGI HDLAGRTRYS YFHGTSTVLD FVEAPSQMLE NWCWTPSVLK SLSKHWETQE
QIPDELIEKL VSTKRLNSAI GALGQLVIGL FDMTVHTPES HEAVKKLNAG RVWNTLRHEI
SGTKGPEDLG EGLEWGNRHA GIGHFIGGYD AGYYGYLYSE VFSLDMFHSF FAKNPMDGKE
GRRYRHTVLE RGGSIPELEF LREFLGREPS SEAFYKELGL SSTA
//
