ID X0AP08_FUSOX Unreviewed; 1098 AA.
AC X0AP08;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=ADP-ribosylation factor GTPase-activating protein {ECO:0000256|RuleBase:RU369028};
GN ORFNames=FOMG_05440 {ECO:0000313|EMBL:EXK42567.1};
OS Fusarium oxysporum f. sp. melonis 26406.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1089452 {ECO:0000313|EMBL:EXK42567.1};
RN [1] {ECO:0000313|EMBL:EXK42567.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=26406 {ECO:0000313|EMBL:EXK42567.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum melonis.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXK42567.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=26406 {ECO:0000313|EMBL:EXK42567.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum f. sp. melonis
RT 26406.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase-activating protein for the ADP ribosylation factor
CC family. {ECO:0000256|RuleBase:RU369028}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369028}.
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DR EMBL; JH659331; EXK42567.1; -; Genomic_DNA.
DR AlphaFoldDB; X0AP08; -.
DR VEuPathDB; FungiDB:FOMG_05440; -.
DR Proteomes; UP000030703; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08204; ArfGap; 1.
DR CDD; cd07608; BAR_ArfGAP_fungi; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045258; ACAP1/2/3-like.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23180:SF160; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1; 1.
DR PANTHER; PTHR23180; CENTAURIN/ARF; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|RuleBase:RU369028};
KW Cytoplasm {ECO:0000256|RuleBase:RU369028};
KW GTPase activation {ECO:0000256|RuleBase:RU369028};
KW Metal-binding {ECO:0000256|RuleBase:RU369028};
KW Repeat {ECO:0000256|RuleBase:RU369028};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|RuleBase:RU369028};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 634..740
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 815..939
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 517..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 121436 MW; 3B0CC25B61F3EF8C CRC64;
MGIVSSKPEE GPALYLRDQN RLSISSLVVT NPRKRTSVNI VPNAFPATRV SAQRPLGDTS
PVEFVQDPDI SNPTAPPNFL VKLSNDDELI FSFTFVMRQA QLAQPATSSE PASAPIDTSI
SGLTYVYASN LKEVENLVTR EFHADPNLHR NANVALVGDY TTGGSPSVSF EWTWKWKPPK
PTEDKGGGWR NSCSFVEYDP RAHRLHTLAS FSYFVAGTPA SLSHPNSPSP PFLLASPPKI
RVASSQSVDS RITAPDIIDE PVSPLIPTAE MPLTPGFPQA KETVKVDVAC PKPNEESMVS
DDGPVFRATL KALEQKTGNM RTQMKKVLKK AEHAHSCQIE ANDAFTAFVD ALREAAATNA
NAVQPALTHY FDKIAREILS YERQNTYNLQ KIIIEPVTKL YQVDIKQAES KKRDFEEESK
DYYAYVSRYL GQRQDSVKAK KLAEADSKYQ NKRRNFELKR FDYSSFMQDL HGGRKEQEVL
SHLTRFADAQ TRGFMATAKK IEVLLPQLEA LSNEVQEADK EYQYQRRERE EKRRLLEKSN
TPYKEPEQNS TASNTPVGSA TNGNTGNTSD SDLGRADSTG SQLNAGSVNV PSGVELSRSP
GSLGQTGVGS PAAASKFKGI RDLEERDNMP SAVTHRKEGL LWALNRPGGH VDPRNLNKQG
WHKFWIVLDQ GKLSEYSNWK QKLDLHIDPI DLRMASVREA RNAERRFCFE VITPSFKRVY
QATSEEDMNS WITAINNALQ SAMEGRSYQG KPTSSNGDSS LRRDIGSVLT GKTQSLSHGN
HHSTANTGIP SRRITVGARP SAVRTSSSGY DENPDRVLQM VRDNDQGNLW CADCGSGSKV
EWVSINLGII LCIECSGIHR SLGTHISKVR SLTLDIKSFT IDIVELLLLI GNRVSNMIWE
AKLDQSLKPT AQASREQRLR FITSKYVDRL FVEPISPTLS RYGTADETLL AAIKKNEIQQ
VLYALALKAN PNTVDKMRGT HAVWLALAAA DPAAPSPGTP HTVTDAEAKA VPFPVAELLV
QNGAEIPATM PAFPLGRFAQ IYVEQKRGRT VIEGSMDAVP SLPSNMSPAE RLQREKEARL
QKRVSTGGRL ARSPIPER
//
