ID X1WCP8_DANRE Unreviewed; 476 AA.
AC X1WCP8; A0A8M6Z522;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 2 {ECO:0000313|RefSeq:XP_017210240.1};
DE SubName: Full=Beta-1,4-N-acetyl-galactosaminyl transferase 2, tandem duplicate 2 {ECO:0000313|Ensembl:ENSDARP00000127995};
GN Name=b4galnt2.2 {ECO:0000313|Ensembl:ENSDARP00000127995,
GN ECO:0000313|RefSeq:XP_017210240.1,
GN ECO:0000313|ZFIN:ZDB-GENE-130530-731};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000127995};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000127995, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127995,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000127995}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127995};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_017210240.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017210240.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL935200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT573473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017210240.1; XM_017354751.2.
DR Ensembl; ENSDART00000157090; ENSDARP00000127995; ENSDARG00000070605.
DR Ensembl; ENSDART00000157090.3; ENSDARP00000127995.1; ENSDARG00000070605.6.
DR GeneID; 557782; -.
DR KEGG; dre:557782; -.
DR AGR; ZFIN:ZDB-GENE-130530-731; -.
DR CTD; 557782; -.
DR ZFIN; ZDB-GENE-130530-731; b4galnt2.2.
DR HOGENOM; CLU_036051_0_0_1; -.
DR OMA; KVNGPNI; -.
DR OrthoDB; 3831416at2759; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000070605; Expressed in ovary and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008376; F:acetylgalactosaminyltransferase activity; IBA:GO_Central.
DR GO; GO:0019276; P:UDP-N-acetylgalactosamine metabolic process; IBA:GO_Central.
DR GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IBA:GO_Central.
DR CDD; cd00761; Glyco_tranf_GTA_type; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR15046:SF2; BETA-1,4 N-ACETYLGALACTOSAMINYLTRANSFERASE 2; 1.
DR PANTHER; PTHR15046; GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 238..340
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
SQ SEQUENCE 476 AA; 54262 MW; 5F05DECF0A459B79 CRC64;
MNCKHHLLLK GFLLLLAICF IQLGIMSVKK DIIASSSGPQ PGKVFAKPHI ETFLYTNRLS
CSLEDAVLTR QHVPQNELED IVKRRAEEYR QHQIRMEADI ASLILAPANS PLQYPITGFT
ISPLKKSIVP GLALHAQQRK VYKVSLSVMS GVLSVEDVQD EQVEGQGQSE LIISSSNLTQ
LNDLLSRVSY TSTVYHIKTS DLVIFSFEDH LAMFPITIKR QSVPVLFDPG NDINSQVTII
TKTFLRYEEL NILLNSIRKF YPKIKILIAD DSIQPRTVSG DNIEHYIMPP AKGWFAGRNL
ALSQVETKYF LWVDDDFVFL KDTRIESFVE IMEAVPELDI LGGSVIGDPP YFILEYDEGD
EEEGGCLSRI YNQFHQPLPG FDDCVLVDGV VNYFLARTDA VRRVGFDPFL KRVAHSEFFM
DGLGQLLVAS CERFTIGHQG HRFEKKYSHY RTQTDADKRK KLSHHFFKNY LKYVKF
//
