ID X1WD04_DANRE Unreviewed; 160 AA.
AC X1WD04; A0A8M1P7I6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=maleylacetoacetate isomerase {ECO:0000256|ARBA:ARBA00013199};
DE EC=5.2.1.2 {ECO:0000256|ARBA:ARBA00013199};
GN Name=gstz1 {ECO:0000313|Ensembl:ENSDARP00000128101,
GN ECO:0000313|RefSeq:NP_001306763.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040718-184};
GN Synonyms=zgc:113898 {ECO:0000313|RefSeq:NP_001306763.1}, zgc:92869
GN {ECO:0000313|RefSeq:NP_001306763.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000128101};
RN [1] {ECO:0000313|RefSeq:NP_001306763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RX PubMed=23770340;
RA Timme-Laragy A.R., Goldstone J.V., Imhoff B.R., Stegeman J.J., Hahn M.E.,
RA Hansen J.M.;
RT "Glutathione redox dynamics and expression of glutathione-related genes in
RT the developing embryo.";
RL Free Radic. Biol. Med. 65:89-101(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000128101, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128101};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000128101}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128101};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001306763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RX PubMed=25461745;
RA Glisic B., Mihaljevic I., Popovic M., Zaja R., Loncar J., Fent K.,
RA Kovacevic R., Smital T.;
RT "Characterization of glutathione-S-transferases in zebrafish (Danio
RT rerio).";
RL Aquat. Toxicol. 158:50-62(2015).
RN [5] {ECO:0000313|RefSeq:NP_001306763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001306763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_001306763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RX PubMed=27086301; DOI=10.1007/s00128-016-1798-3;
RA Garcia-Reyero N., Escalon L., Prats E., Faria M., Soares A.M., Raldua D.;
RT "Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon
RT Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes.";
RL Bull. Environ. Contam. Toxicol. 96:707-713(2016).
RN [8] {ECO:0000313|RefSeq:NP_001306763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [9] {ECO:0000313|RefSeq:NP_001306763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RX PubMed=29361160;
RA Tierbach A., Groh K.J., Schonenberger R., Schirmer K., Suter M.J.;
RT "Glutathione S-Transferase Protein Expression in Different Life Stages of
RT Zebrafish (Danio rerio).";
RL Toxicol. Sci. 162:702-712(2018).
RN [10] {ECO:0000313|RefSeq:NP_001306763.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001306763.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate;
CC Xref=Rhea:RHEA:14817, ChEBI:CHEBI:17105, ChEBI:CHEBI:18034;
CC EC=5.2.1.2; Evidence={ECO:0000256|ARBA:ARBA00001622};
CC -!- COFACTOR:
CC Name=glutathione; Xref=ChEBI:CHEBI:57925;
CC Evidence={ECO:0000256|ARBA:ARBA00001955};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC {ECO:0000256|ARBA:ARBA00004671}.
CC -!- SIMILARITY: Belongs to the GST superfamily. Zeta family.
CC {ECO:0000256|ARBA:ARBA00010007}.
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DR EMBL; FO704844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001306763.1; NM_001319834.1.
DR Ensembl; ENSDART00000157338; ENSDARP00000128101; ENSDARG00000027984.
DR Ensembl; ENSDART00000157338.3; ENSDARP00000128101.2; ENSDARG00000027984.9.
DR GeneID; 436754; -.
DR AGR; ZFIN:ZDB-GENE-040718-184; -.
DR CTD; 2954; -.
DR ZFIN; ZDB-GENE-040718-184; gstz1.
DR eggNOG; KOG0868; Eukaryota.
DR OrthoDB; 986565at2759; -.
DR UniPathway; UPA00139; UER00340.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000027984; Expressed in liver and 20 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004364; F:glutathione transferase activity; IDA:ZFIN.
DR GO; GO:0016034; F:maleylacetoacetate isomerase activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IBA:GO_Central.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd03191; GST_C_Zeta; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR005955; GST_Zeta.
DR InterPro; IPR034330; GST_Zeta_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR01262; maiA; 1.
DR PANTHER; PTHR42673; MALEYLACETOACETATE ISOMERASE; 1.
DR PANTHER; PTHR42673:SF4; MALEYLACETOACETATE ISOMERASE; 1.
DR Pfam; PF00043; GST_C; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW Isomerase {ECO:0000313|RefSeq:NP_001306763.1};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Proteomics identification {ECO:0007829|PeptideAtlas:X1WD04};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 1..32
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 37..156
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 160 AA; 18155 MW; 976ABA15FA4CBA3F CRC64;
MQQVPAVSID GITLSQSLAI IQYIEETRPE PRLLPADPMQ RAHVRIICDI IASGIQPLQN
LYVLQKIGED KVQWAQHFIN RGFQALEPVL KETAGKYCVG DEISMADICL VPQVYNADRF
KVDMTQYPTI RRLNQTLVEI EAFKASHPSR QPDTPDDLRL
//
