ID X1WD98_DANRE Unreviewed; 1644 AA.
AC X1WD98; A0A8M1RFH4;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=E3 ubiquitin-protein ligase SHPRH isoform X1 {ECO:0000313|RefSeq:XP_003200358.1};
DE SubName: Full=SNF2 histone linker PHD RING helicase {ECO:0000313|Ensembl:ENSDARP00000128195};
GN Name=shprh {ECO:0000313|Ensembl:ENSDARP00000128195,
GN ECO:0000313|RefSeq:XP_003200358.1,
GN ECO:0000313|ZFIN:ZDB-GENE-110512-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000128195};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000128195, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128195};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000128195}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128195};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_003200358.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_003200358.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX296541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX511121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003200358.1; XM_003200310.5.
DR STRING; 7955.ENSDARP00000128195; -.
DR PaxDb; 7955-ENSDARP00000128195; -.
DR Ensembl; ENSDART00000157123; ENSDARP00000128195; ENSDARG00000075884.
DR Ensembl; ENSDART00000157123.2; ENSDARP00000128195.1; ENSDARG00000075884.5.
DR GeneID; 560526; -.
DR KEGG; dre:560526; -.
DR AGR; ZFIN:ZDB-GENE-110512-2; -.
DR CTD; 257218; -.
DR ZFIN; ZDB-GENE-110512-2; shprh.
DR eggNOG; KOG0298; Eukaryota.
DR HOGENOM; CLU_001726_1_1_1; -.
DR OrthoDB; 8175at2759; -.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000075884; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd18070; DEXQc_SHPRH; 1.
DR CDD; cd00073; H15; 1.
DR CDD; cd15547; PHD_SHPRH; 1.
DR CDD; cd16569; RING-HC_SHPRH-like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048686; SHPRH_helical_1st.
DR InterPro; IPR048695; SHPRH_helical_2nd.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45865:SF1; E3 UBIQUITIN-PROTEIN LIGASE SHPRH; 1.
DR PANTHER; PTHR45865; E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00538; Linker_histone; 1.
DR Pfam; PF21325; SHPRH_helical-1st; 1.
DR Pfam; PF21324; SHPRH_helical-2nd; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00526; H15; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51504; H15; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:X1WD98};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 411..485
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 1393..1440
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1475..1633
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 62..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1644 AA; 187408 MW; B2A7D85A3C891870 CRC64;
MSSRRKRAPP VRVDEDAKRR LDWNMHEDRK NEGACEDILE SVPAPSDSCL PVPVLEQGFI
SSAGTEEEPS EERPSCSTQD SPPDTIELNV MPISVLDQGW NALIGEFNLH PKIPIEVADG
SFCLQQTGDT LSMTLNTLEM EDGRGRSDPL CSVPVACSLG GLLLEDLDWL QKRKVIKLCH
ASGGVPVKLK VFLIESGLGR PEFLSEGNGR IKKASQLLQK LMELFYDFII PEVMENEEEA
CDTDLERQNV EELYDHVRHL HQTEAAEQSF HVQHPALIPI LRPYQSQAVN WMLRREKYKS
SSSPEQRLHF LWREMVTICG KKLFYNPYTG CLIREFPLAG VDWPGGILAD EMGLGKTVEV
LALILCNTRQ NLEHGVLTLP VGRSVNYFVP PPPLERQRII KHEPRPKEKI IYPAVREMLL
TAIKEMKVGK GASINAIFAY LRTMYKYDTL KNRNHIKKIL TKLISENIVE QIKGRGLAGS
FKLGKNYKEK KKKPVTARTK SADQPAPRRT SRRVSAPDKD SSLTSYTTTA SDSASEDSMN
PPLLTEELKS DPDSLLDPEN PLQKKPVDIT DDKEIPDKPQ LQITEDVHIE SNKPDLMQTS
KPEVETPTRA SVVPFNTPDY RFECICGELG LVDYKPRVQC LNCLLWQHAE CVNYKEENLE
TTPFYCPHCL VAMTPVSTGA TLIISPSSIC HQWVDEINRH IHTSSLRVLV YQGVKRHGFI
QPHILAEQDV VITTYDVLRT ELNYVDIPHS NSKDGRRFRN QKRYMAIPSP LVAVEWWRVC
LDEAQMVECT TAKAAEMALR LTSVNRWCVS GTPVQRGLED LYGLVLFLGV DPYWVKYWWD
QLLYRPYRHG NTAPLYNVIG QLLWRSAKKD VIDQIQIPPQ TEEIHWLNFS PVERHFYHRQ
HEVCSQDALV KLRKISDWSL KLGSLDRRTV TTILYPLLRL RQACCHPQAV RGEFLPLQKS
TMTMEELLKS LQKKCRVECE EAHRQLVCAL NGLAGIHIIR SEFVDAAEMY REVLRSSEEH
KARLKTDSLQ RLHATHNLME LLSANHPGIP PTLRDDSLKE EAEQLKQHYM AKVNSEVSEA
HQNLQPVLQH IKEQRRKVNL RSPWWLDVIQ QAMQYSMDDD LVSRIQNELT CSYKQQANKL
SMADKFRDAR GLQFLLSTQM DDLMKSQKTV QDAVKKLEGP PSQQVIEEAT LCHLRPVRLP
LNNCVFCKAD ELFTDYESKL FSHTVKGQTA IFEEMIEDEE GLVDDRLPTT SRGLWAASET
ERALKAILSF AKVRRLESGL IEEGNSFMEL FESWKKEYKL LHEYWMSLRD HVSAIDELGM
ATERLRVRLP DEPKPKVLHI IEPHEVEQNR IKLLNDRAVA KSQLQKKLGQ FLYLTNLEKS
QDKSTGGLNP EPCPICARPL GQEWAVLTCG HCFCNECIAI IVEQYSIGNR RRAIKCAICR
QTTSHAEISY VFTTQNNHQG QDIPVKGSHS TKVEAVVRVL KKVQMTDPGA KSLVFSTWQG
VLDIIAKALF DNNMEFAQIN GIHKFQENLS AFKYEEKINI LLLPLHTGSN GLNIIEATHV
LLVEPILNPA HELQAIGRVH RIGQTKPTFV HRFLIKSTIE ERMQAMLKTA EKSHSSTSMK
HSEASVFTVA DLADLFTEDS ETLE
//
