GenomeNet

Database: UniProt
Entry: X1WH66_DANRE
LinkDB: X1WH66_DANRE
Original site: X1WH66_DANRE 
ID   X1WH66_DANRE            Unreviewed;       620 AA.
AC   X1WH66;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   25-OCT-2017, entry version 27.
DE   SubName: Full=Cyclic nucleotide-gated channel alpha 1 {ECO:0000313|Ensembl:ENSDARP00000129576};
GN   Name=cnga1 {ECO:0000313|Ensembl:ENSDARP00000129576,
GN   ECO:0000313|ZFIN:ZDB-GENE-110408-39};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000129576, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000129576, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129576,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000129576}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129576};
RG   Ensembl;
RL   Submitted (MAR-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000129576}.
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DR   EMBL; CR318612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; X1WH66; -.
DR   Ensembl; ENSDART00000156842; ENSDARP00000129576; ENSDARG00000012125.
DR   ZFIN; ZDB-GENE-110408-39; cnga1.
DR   eggNOG; KOG0500; Eukaryota.
DR   eggNOG; ENOG410YWWI; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   Reactome; R-DRE-2485179; Activation of the phototransduction cascade.
DR   Reactome; R-DRE-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR   Proteomes; UP000000437; Chromosome 23.
DR   Bgee; ENSDARG00000012125; -.
DR   ExpressionAtlas; X1WH66; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005221; F:intracellular cyclic nucleotide activated cation channel activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR032406; CLZ_dom.
DR   InterPro; IPR032945; CNGA1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF387; PTHR10217:SF387; 1.
DR   Pfam; PF16526; CLZ; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    118    138       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    150    170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    256    274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      432    538       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED       38    111       {ECO:0000256|SAM:Coils}.
FT   COILED      587    618       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   620 AA;  72348 MW;  D405430F0CAE7D79 CRC64;
     MSARVRPLDP PRFLVEGMEQ VTMEDVIENK RPDAGALFNN TNNSNNNEEE DKKKKKKEKK
     EKKEKKEKKE KKEKKEKKKE QEEKEKEKEK EKEKEKEKEK EKEKLKEIEV VDPAGNMYYN
     WLFVITCPVM YNWIFIIARA CFEELQGDYL ILWFFLDYLS DAVYLLDMVF RTRTGYLEQG
     LLVKDQKKLR DRYTDSLQFR LDLASMVPTD IFYLYFGMNY PEIRMNKLLR INRLFEFFQR
     TETRTNFPNV FRISNLVMYI VIIIHWNACM YYSFSKAIGF GSDAFVYPDP SDPEFGRLVR
     KYAYSMYWST LTLTTIGETP PPVENSEYFF VVTDFLVGVL IFATIVGNVG SMITNANAAR
     ADFQARIDAI KQYMSFRKVT KDLEKRVIKW FDYLWTNKKA VDEREVLKYL PDKLRAEIAI
     NVHLDTLKKV RIFADCEAGL LVELVLKLQP QVYSPGDYIC KKGDIGREMY IIKEGKLAVV
     ADDGITQFVV LSDGSYFGEI SILNIKGSRA GNRRTANIRS IGYSDLFCLS KDDLMEALTE
     YPDAKAMLEE KGRQILMKDN LLDLELAKQG PDPKDMEEKV QKIGGVLEDL QTRFARLLAE
     QEAAQGKLKK RVTKLEKKMT
//
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