ID   X2HAC5_9NEIS            Unreviewed;       456 AA.
AC   X2HAC5;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Succinate-semialdehyde dehydrogenase [NAD] Succinate-semialdehyde dehydrogenase [NADP+] {ECO:0000313|EMBL:AHN28042.1};
DE            EC=1.2.1.16 {ECO:0000313|EMBL:AHN28042.1};
DE            EC=1.2.1.24 {ECO:0000313|EMBL:AHN28042.1};
GN   ORFNames=SALWKB2_0660 {ECO:0000313|EMBL:AHN28042.1};
OS   Snodgrassella alvi wkB2.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Snodgrassella.
OX   NCBI_TaxID=1196094 {ECO:0000313|EMBL:AHN28042.1, ECO:0000313|Proteomes:UP000019668};
RN   [1] {ECO:0000313|EMBL:AHN28042.1, ECO:0000313|Proteomes:UP000019668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WkB2 {ECO:0000313|EMBL:AHN28042.1};
RX   PubMed=25053814;
RA   Kwong W.K., Engel P., Koch H., Moran N.A.;
RT   "Genomics and host specialization of honey bee and bumble bee gut
RT   symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:11509-11514(2014).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP007446; AHN28042.1; -; Genomic_DNA.
DR   RefSeq; WP_025330278.1; NZ_CP091515.1.
DR   AlphaFoldDB; X2HAC5; -.
DR   STRING; 1196094.SALWKB2_0660; -.
DR   GeneID; 32537916; -.
DR   KEGG; salv:SALWKB2_0660; -.
DR   PATRIC; fig|1196094.4.peg.660; -.
DR   HOGENOM; CLU_005391_1_0_4; -.
DR   OrthoDB; 6187633at2; -.
DR   Proteomes; UP000019668; Chromosome.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
DR   GO; GO:0004777; F:succinate-semialdehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   CDD; cd07100; ALDH_SSADH1_GabD1; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR044148; ALDH_GabD1-like.
DR   InterPro; IPR047110; GABD/Sad-like.
DR   PANTHER; PTHR43217; SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD; 1.
DR   PANTHER; PTHR43217:SF2; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          3..451
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        230
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   456 AA;  49776 MW;  4E5B86105ACE8F01 CRC64;
     MAYQSINPFT GELARTFSNH TNTEVENVLT QAHALYKSEW SQPENISERQ ALLQRLAEIM
     TRHQEKIARI ITLDMGKRIA ESRNEIVNCI EIVQYYAKQA AELLKPAAYP SKLGKGWVEH
     HPIGIILAVE PWNFPIYQLI RVIAPAIAVG NPVVAKHASN VPQCAQLVED LLHEAQAPAG
     TYTNLFVTPE QIETIIGDKR VQGVALTGSE GAGIIVAGQA GSKLKKSTME LGGNDVFVVT
     DDADVVAAAH TAVAGRLFNA GQVCIAAKRF IVHEKVAEQF TRIVQEDFAQ VVMGDPLDEN
     TTLAPLSSRK SKDTLQEQLD AAIAHGAKVI CGNKPAKGNF FTPTLITDIS RDNPAYFEEF
     FGPVAQLYIV KNDEEAITLA NDSNFGLGGT VFSKDIERAK KLASRIETGM VFINRFGDSV
     AELPFGGIKR SGFGRELSDL GIKEFVNHKL VVLAQD
//