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Database: UniProt
Entry: X2HAF0_9NEIS
LinkDB: X2HAF0_9NEIS
Original site: X2HAF0_9NEIS 
ID   X2HAF0_9NEIS            Unreviewed;       516 AA.
AC   X2HAF0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   05-JUL-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SALWKB2_1988 {ECO:0000313|EMBL:AHN29370.1};
OS   Snodgrassella alvi wkB2.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Snodgrassella.
OX   NCBI_TaxID=1196094 {ECO:0000313|EMBL:AHN29370.1, ECO:0000313|Proteomes:UP000019668};
RN   [1] {ECO:0000313|EMBL:AHN29370.1, ECO:0000313|Proteomes:UP000019668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WkB2 {ECO:0000313|EMBL:AHN29370.1};
RX   PubMed=25053814;
RA   Kwong W.K., Engel P., Koch H., Moran N.A.;
RT   "Genomics and host specialization of honey bee and bumble bee gut
RT   symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:11509-11514(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007446; AHN29370.1; -; Genomic_DNA.
DR   EnsemblBacteria; AHN29370; AHN29370; SALWKB2_1988.
DR   KEGG; salv:SALWKB2_1988; -.
DR   PATRIC; fig|1196094.4.peg.1989; -.
DR   KO; K02313; -.
DR   Proteomes; UP000019668; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019668};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019668}.
FT   DOMAIN      213    343       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      424    493       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     221    228       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   516 AA;  57417 MW;  BC9EB4501D56B176 CRC64;
     MWIAPLTVGE ENGNWVIFAR NTFTFNHIRE RFWPAIENAR QSVLPDGSTP LILKIGQGLS
     LQAATEAIPA GNNSPVKTAE PDLNVAEQPA DIKPDSVNTN KIHSEVSTKP QTTAKRTESA
     QDIIAKRLRN TQTKSASATA ETKENSKQTA TEKPEAGESV ATSDSAHENG KKSRYTDTNL
     NPEHTFAALV QGKGNRLAHA AALSIAENPG NSMYNPFFIY GSTGLGKTHL VQAIGNQLFA
     TDNKVKIRYI HADEFIRGIM NAFHAKSFDA MRQQYQQVDL LIMDDVQFIA GKDRTMEEFF
     YVYNHLIDEK KQVILTCDTL PTHIDGMDDR LKSRFSWGLS LELEPPELEM RVAILQKKAE
     MAQVKLEDEA AFFIAKHIRS NVRELEGAFK RVVAQSRFAS RPIDVGLATE ALQDILAVNH
     KPMTLEHIQN TVAKFYGITI SDMVGKKRTR NLARPRQMAM TLAKELTPLS LPAIGSGFGG
     RDHTTVMHAV KSISKLRKDD AETTKAYETL MMILRD
//
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