GenomeNet

Database: UniProt
Entry: X2JFE8_DROME
LinkDB: X2JFE8_DROME
Original site: X2JFE8_DROME 
ID   X2JFE8_DROME            Unreviewed;      2055 AA.
AC   X2JFE8;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-SEP-2017, entry version 33.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|EMBL:AHN59803.1,
GN   ECO:0000313|FlyBase:FBgn0285944};
GN   Synonyms=bas {ECO:0000313|EMBL:AHN59803.1}, bss
GN   {ECO:0000313|EMBL:AHN59803.1}, Dmel\CG9907
GN   {ECO:0000313|EMBL:AHN59803.1}, DmNa[[V]]
GN   {ECO:0000313|EMBL:AHN59803.1}, DmNa[[v]]
GN   {ECO:0000313|EMBL:AHN59803.1}, DmNa[[v]]1
GN   {ECO:0000313|EMBL:AHN59803.1}, DmNav1 {ECO:0000313|EMBL:AHN59803.1},
GN   l(1)14Da {ECO:0000313|EMBL:AHN59803.1}, l(1)ESHS48
GN   {ECO:0000313|EMBL:AHN59803.1}, lincRNA.S9469
GN   {ECO:0000313|EMBL:AHN59803.1}, Ocd {ECO:0000313|EMBL:AHN59803.1}, olfD
GN   {ECO:0000313|EMBL:AHN59803.1}, par {ECO:0000313|EMBL:AHN59803.1}, sbl
GN   {ECO:0000313|EMBL:AHN59803.1}, sbl-1 {ECO:0000313|EMBL:AHN59803.1};
GN   ORFNames=CG9907 {ECO:0000313|EMBL:AHN59803.1,
GN   ECO:0000313|FlyBase:FBgn0285944}, Dmel_CG9907
GN   {ECO:0000313|EMBL:AHN59803.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
RN   [5] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AHN59803.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AE014298; AHN59803.1; -; Genomic_DNA.
DR   RefSeq; NP_001285333.1; NM_001298404.1.
DR   UniGene; Dm.22809; -.
DR   PaxDb; X2JFE8; -.
DR   PRIDE; X2JFE8; -.
DR   EnsemblMetazoa; FBtr0344944; FBpp0311217; FBgn0264255.
DR   GeneID; 32619; -.
DR   CTD; 32619; -.
DR   FlyBase; FBgn0285944; para.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   ChiTaRS; Prm; fly.
DR   GenomeRNAi; 32619; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0264255; -.
DR   ExpressionAtlas; X2JFE8; differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    204    226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    238    256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    262    284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    394    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    799    822       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    843    860       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    872    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    931    950       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    971    990       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1005   1028       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1331   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1357   1377       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1458   1484       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1547   1565       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1577   1596       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1608   1627       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1671   1694       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1757   1780       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1801   1836       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      420    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2055 AA;  230840 MW;  EB3D2210233DCB46 CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEI RYDDEDEDEG
     PQPDPTLEQG VPIPVRLQGS FPPELASTPL EDIDPYYSNV LTFVVVSKGK DIFRFSASKA
     MWMLDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTVESTE VIFTGIYTFE
     SAVKVMARGF ILCPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA
     IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KKFPLDGSWG
     NLTDENWDYH NRNSSNWYSE DEGISFPLCG NISGAGQCDD DYVCLQGFGP NPNYGYTSFD
     SFGWAFLSAF RLMTQDFWED LYQLVLRAAG PWHMLFFIVI IFLGSFYLVN LILAIVAMSY
     DELQKKAEEE EAAEEEAIRE AEEAAAAKAA KLEERANAQA QAAADAAAAE EAALHPEMAK
     SPTYSCISYE LFVGGEKGND DNNKEKMSIR SVEVESESVS VIQRQPAPTT AHQATKVRKV
     STTSLSLPGS PFNIRRGSRS SHKYTIRNGR GRFGIPGSDR KPLVLSTYQD AQQHLPYADD
     SNAVTPMSEE NGAIIVPVYY GNLGSRHSSY TSHQSRISYT SHGDLLGGMA VMGVSTMTKE
     SKLRNRNTRN QSVGATNGGT TCLDTNHKLD HRDYEIGLEC TDEAGKIKHH DNPFIEPVQT
     QTVVDMKDVM VLNDIIEQAA GRHSRASDRG VSVYYFPTED DDEDGPTFKD KALEVILKGI
     DVFCVWDCCW VWLKFQEWVS LIVFDPFVEL FITLCIVVNT MFMAMDHHDM NKEMERVLKS
     GNYFFTATFA IEATMKLMAM SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR
     LLRVFKLAKS WPTLNLLISI MGRTMGALGN LTFVLCIIIF IFAVMGMQLF GKNYHDHKDR
     FPDGDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMYVG DVSCIPFFLA TVVIGNLVVL
     NLFLALLLSN FGSSSLSAPT ADNDTNKIAE AFNRIGRFKS WVKRNIADCF KLIRNKLTNQ
     ISDQPSEHGD NELELGHDEI LADGLIKKGI KEQTQLEVAI GDGMEFTIHG DMKNNKPKKS
     KYLNNATDDD TASINSYGSH KNRPFKDESH KGSAETMEGE EKRDASKEDL GLDEELDEEG
     ECEEGPLDGD IIIHAHDEDI LDEYPADCCP DSYYKKFPIL AGDDDSPFWQ GWGNLRLKTF
     QLIENKYFET AVITMILMSS LALALEDVHL PQRPILQDIL YYMDRIFTVI FFLEMLIKWL
     ALGFKVYFTN AWCWLDFVIV MVVVNALVQA IPSIFNVLLV CLIFWLIFAI MGVQLFAGKY
     FKCEDMNGTK LSHEIIPNRN ACESENYTWV NSAMNFDHVG NAYLCLFQVA TFKGWIQIMN
     DAIDSREVDK QPIRETNIYM YLYFVFFIIF GSFFTLNLFI GVIIDNFNEQ KKKAGGSLEM
     FMTEDQKKYY NAMKKMGSKK PLKAIPRPRW RPQAIVFEIV TDKKFDIIIM LFIGLNMFTM
     TLDRYDASDT YNAVLDYLNA IFVVIFSSEC LLKIFALRYH YFIEPWNLFD VVVVILSILG
     LVLSDIIEKY FVSPTLLRVV RVAKVGRVLR LVKGAKGIRT LLFALAMSLP ALFNICLLLF
     LVMFIFAIFG MSFFMHVKEK SGINDVYNFK TFGQSMILLF QMSTSAGWDG VLDAIINEEA
     CDPPDNDKGY PGNCGSATVG ITFLLSYLVI SFLIVINMYI AVILENYSQA TEDVQEGLTD
     DDYDMYYEIW QQFDPEGTQY IRYDQLSEFL DVLEPPLQIH KPNKYKIISM DIPICRGDLM
     YCVDILDALT KDFFARKGNP IEETGEIGEI AARPDTEGYE PVSSTLWRQR EEYCARLIQH
     AWRKHKARGE GGGSFEPDTD HGDGGDPDAG DPAPDEATDG DAPAGGDGSV NGTAEGAADA
     DESNVNSPGE DAAAAAAAAA AAAAAGTTTA GSPGAGSAGR QTAVLVESDG FVTKNGHKVV
     IHSRSPSITS RTADV
//
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