ID X2JFL7_DROME Unreviewed; 2016 AA.
AC X2JFL7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Raskol, isoform I {ECO:0000313|EMBL:AHN59858.1};
GN Name=raskol {ECO:0000313|EMBL:AHN59858.1,
GN ECO:0000313|FlyBase:FBgn0261570};
GN Synonyms=CG15816 {ECO:0000313|EMBL:AHN59858.1}, CG32559
GN {ECO:0000313|EMBL:AHN59858.1}, CG32560 {ECO:0000313|EMBL:AHN59858.1},
GN CG42270 {ECO:0000313|EMBL:AHN59858.1}, CG5898
GN {ECO:0000313|EMBL:AHN59858.1}, CG5960 {ECO:0000313|EMBL:AHN59858.1},
GN Dmel\CG42684 {ECO:0000313|EMBL:AHN59858.1}, FBpp0112350
GN {ECO:0000313|EMBL:AHN59858.1};
GN ORFNames=CG42684 {ECO:0000313|EMBL:AHN59858.1,
GN ECO:0000313|FlyBase:FBgn0261570}, Dmel_CG42684
GN {ECO:0000313|EMBL:AHN59858.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AHN59858.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE014298; AHN59858.1; -; Genomic_DNA.
DR RefSeq; NP_001285388.1; NM_001298459.1.
DR SMR; X2JFL7; -.
DR DNASU; 32754; -.
DR EnsemblMetazoa; FBtr0340632; FBpp0309496; FBgn0261570.
DR GeneID; 32754; -.
DR AGR; FB:FBgn0261570; -.
DR CTD; 32754; -.
DR FlyBase; FBgn0261570; raskol.
DR VEuPathDB; VectorBase:FBgn0261570; -.
DR GeneTree; ENSGT00940000172132; -.
DR OMA; EAPSMKN; -.
DR OrthoDB; 22721at2759; -.
DR BioGRID-ORCS; 32754; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG42684; fly.
DR GenomeRNAi; 32754; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0261570; Expressed in egg cell and 21 other cell types or tissues.
DR ExpressionAtlas; X2JFL7; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd13262; PH_RasSynGAP-like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF125; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Proteomics identification {ECO:0007829|PeptideAtlas:X2JFL7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 711..829
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 903..1097
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1763..1872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1997..2016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 344..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1569..1600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1713..1736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1807..1840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2016 AA; 219526 MW; E7B0C02BC3ABD80A CRC64;
MLQAASSTTT APVGNTADTG NSESPIIATP EEKSQRRRST FYVPLVIEDE EETKKDTPAD
HLVQKSSSNT SLSSNSNSLT NSETKSSKSY SLRKSSSVKS GVAKVSALFE RKTPSKMSPP
CGFNWSISGS ENTAQYSDTD DDEENSTEAR HREQLLKTLP SGNNNSTTAS PSKLKRYGIV
LNVISLNGSD NEQSSLGSNG SSMPSMPSMP NGQNIPNAAA PRTHFNEEND IVLATPPPPK
QQALSAAHES NDYDDDSEIS RMQTNTSTPI KLMKSRSRTN ILAVPLPSVE RGLATTNTTP
NNNNINGNSN GSTSNTTTTT TTTTLITLRA KSKTLPQNLS PSVVLREAAA LDELEKKREK
YQEKQEKREK LQEKQRQLFG GSTASQIAGS SPYKLQNSCS ATSILTHSFP PKNLFLLKST
PKLSTDIAAA TPPNTSAICS PPKKSLSFIR RAHSTKVARS NSLLKPNQAG ILGSGSGSNG
LGVHQGVMQG ALSISCAGDN SSNNGSWGKH FYQPYDVCPL SLDELNCYFQ ADQCEKLICE
RFKIRDLAIH MASASAIGAD LSVTTENETT ATADDDAGHH SDTSYEKACR RGSAPTTPIL
GSKQHQTEHN ATSRFTNFFS KKSNPLKRTK SVTKLERTKR GSGGLRGSRS HESLLSSHAV
MSTIDLSCTG AVGVAPVHQS VLGRRHCFQV RGGPRGERYY SCGSRQERDL WIYSLRKSIA
PNAEHTRRTD NSLKMWVYEA KNLPPKKRYF CELQLDKTLY GRTSVKLQTD LLFWGEHFDF
PDIPEINVIT VNVFREVDKK KKRDKYQFVG SVKIPVHDVT SRLPCEQWYP ILSDKAGDSL
GRTSGGGGSG SKDKEQLPTL RIKCRFQSTD ILPINVYGNF LTYLKENYKR VCETLEPVIG
VKAKEDIGQA LVLLMHAQGL AGAFLTDVVA LDLLRVGDQR LTFRGNSLAT KSMEAFLKLT
GEQYLQDTLS APINELIQSE RDCEVDPTKT SGSSAGSLQR QQAALRGAVR GAWQCIFESH
KHFPAQLRNC FATFRERLQQ LGRQDMADNL ISASIFLRFL CPAILSPSLF NITSELPSAR
ATRNLTLVAK TLQTLANFTR FQGKENFMEF LNDFLEQEAA RMQQFLEIIS TRPEHPAPDS
ILDWAGYIDQ GKQLSILHSL LSESLAKLPE ARQHELDPLQ HILDEISRAK EHGMGTALPG
GYLPATSSTH SIASENQENR NPGSSGSHAG SNSEQLLPQQ SQLAQPQHAI VSKPLSAERG
IMRGVLTPNS LEKNIFRYND PTVNGLLQQQ QQQQQQQQQQ QQQHQQLQQH GHQQQPHHQH
PLQMLSNSQT SIAGNQYMSS PGGLQHAQSQ TSMASSSLNG SSSNLLHGHQ QHAHHPQQLH
PHHCPPAPQT SASSTMERMD RMNYPYMSHN GNDYETSTPS STRSRTLPRN GNPNANGNVG
SSNNNQSGSY DDMHGEFQIQ ISGFDTSSAF VCKSPTPMMK SSLGPAGAGR SHHKLNLGIP
DHSGGYVRGN NLNPNSNMPK NLEDLDDLFK YAEEHDVAEP ANHHNHNQGQ QNHQGHLKPA
AVPGKEQLSA KSSHCSSGYQ SISTNPSPSQ SSSPVESQLK AAMGSHNAPL AFKNPSYQLQ
PQTGSSRSSA QSNTHQQQQQ QQQQQFGSRL KPIGGGLVAA RAAFLNSGGA LEAATLTPSS
SDEQLSADNY FSYAAAAAAG AGIATKLEAQ RSLSGGSSSS TSASASTSNL GKSGGSSAYG
RLNGPLKRED VYGSGYGGSS GNVGYGLSTS SAAGHHQHPH QQQQNPMQQQ QQRERDQEHK
QYAGSVAGSV GSATSAAQRR LSLDSARTLS DSSTDTEGHC NQLQEGKRRR QLRSSGGSGG
GGAGSEQGLG KSYDQNGEIQ LLQQTLDTLC HTLDRDEAEL RDSSDELFGL QRPAGSNGSN
NLSLQSESTM RSIIDSFFQS SCRLITMEEE LRREQLKMSL ALSHKQRVIE EQGQQIAALD
AANSRLLSAL TALRQRYETQ QQQQQHQAPP KTQKPQ
//
