ID X2KZL5_9BACT Unreviewed; 284 AA.
AC X2KZL5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
GN Name=bla2 {ECO:0000313|EMBL:AHN92730.1};
OS uncultured bacterium DCM005Cefta01.
OC Bacteria; environmental samples.
OX NCBI_TaxID=1471937 {ECO:0000313|EMBL:AHN92730.1};
RN [1] {ECO:0000313|EMBL:AHN92730.1}
RP NUCLEOTIDE SEQUENCE.
RA Wichmann F., Udikovic-Kolic N., Andrew S., Handelsman J.;
RT "Diverse Antibiotic Resistance Genes in Dairy Cow Manure.";
RL MBio 5:E01017-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526,
CC ECO:0000256|RuleBase:RU361140};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009, ECO:0000256|RuleBase:RU361140}.
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DR EMBL; KJ512936; AHN92730.1; -; Genomic_DNA.
DR AlphaFoldDB; X2KZL5; -.
DR SMR; X2KZL5; -.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR023650; Beta-lactam_class-A_AS.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR PRINTS; PR00118; BLACTAMASEA.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS00146; BETA_LACTAMASE_A; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|RuleBase:RU361140};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..284
FT /note="Beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004950922"
FT DOMAIN 42..256
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
FT REGION 157..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 284 AA; 32046 MW; 0250B0EBD0AB6537 CRC64;
MKKFCFLFLI ICGLMFFCLQ DCQARQKLNL ADLENKYNAV IGVYAVDMEN GKKICYKPDT
RFSYCSTHKV FTVAELLRQK NTSDLNEIRK FSAEDILSYA PITKDHVADG MTLAEICSAS
LRWSDNTAAN LILQEIGGVE NFKVALKNIG DKTTKPARNE PELNLFNPKD NRDTSTPRQM
VKNLQVYIFG DILSDDKKKL LIDWMSDNSI TDTLIKAGTP QGWKVIDKSG SGDYGARNDI
AVIYPPNRKP IVMAIMSRRT EKNAKSDDAM IAEAAKRIFD NLVF
//
