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Database: UniProt
Entry: X4QVL4_9ACTO
LinkDB: X4QVL4_9ACTO
Original site: X4QVL4_9ACTO 
ID   X4QVL4_9ACTO            Unreviewed;       535 AA.
AC   X4QVL4;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   30-AUG-2017, entry version 28.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CQ11_07595 {ECO:0000313|EMBL:AHU89848.1};
OS   Trueperella pyogenes.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Trueperella.
OX   NCBI_TaxID=1661 {ECO:0000313|EMBL:AHU89848.1, ECO:0000313|Proteomes:UP000019771};
RN   [1] {ECO:0000313|EMBL:AHU89848.1, ECO:0000313|Proteomes:UP000019771}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TP6375 {ECO:0000313|EMBL:AHU89848.1,
RC   ECO:0000313|Proteomes:UP000019771};
RX   PubMed=24786956;
RA   Machado V.S., Bicalho R.C.;
RT   "Complete Genome Sequence of Trueperella pyogenes, an Important
RT   Opportunistic Pathogen of Livestock.";
RL   Genome Announc. 2:e00400-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007519; AHU89848.1; -; Genomic_DNA.
DR   RefSeq; WP_025296677.1; NZ_MVGS01000066.1.
DR   EnsemblBacteria; AHU89848; AHU89848; CQ11_07595.
DR   KEGG; tpy:CQ11_07595; -.
DR   PATRIC; fig|1661.13.peg.1523; -.
DR   KO; K02313; -.
DR   Proteomes; UP000019771; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019771};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019771}.
FT   DOMAIN      219    353       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      431    500       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     227    234       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      500    534       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   535 AA;  59691 MW;  B9A06367095D2112 CRC64;
     MDVSPARDAW TAASELLRSQ GKLSDSQAAF IRLAHPLATV EDIFMIGVGS EFVKNWIAEH
     IAAVMEDQLS AILGRSVRLV ISVDPSLTEQ TTQSAPQWHQ PERVLHVVED PVQSPDSFHT
     NDFSAADPFQ AADHSVLPPH EPDFRIPSKP RLVEDVEPED RELSMHASLG AMLPRIEINQ
     DQSDAHLNPR YTFDNFVIGE SNRFAHATAL AVAEAPGSTY NPLFLYSDSG MGKTHLLHAI
     GNYYLSLFPG SKVLYTSSEE FTNMFINAMM KKEGHNFKNL FRSVDILLID DIQFLSNKEG
     TLEEFFNTFN ALATANKQIV ITSDVAPRLL EGFEERMISR FASGIVANID LPNLETRIAI
     LEKKAASEKF MVPREVLEFI ASRVTTNVRE MEGSLRRVTA YAGLFNMPVT LDVAESALKD
     MMSDPSSVTV TAGLIMNQVS AYFGITAGDL KSPTRTRSLT QPRHIAMYMC REMTDLSLPK
     IAEAFNRRDH TTVLNALRKI ESLMTEKQEI FNQVTELTSR IKQAAKEQAQ LADNH
//
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