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Database: UniProt
Entry: X5CF87_HUMAN
LinkDB: X5CF87_HUMAN
Original site: X5CF87_HUMAN 
ID   X5CF87_HUMAN            Unreviewed;       250 AA.
AC   X5CF87;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AHW47982.1};
GN   Name=HLA-DOA {ECO:0000313|EMBL:AHW47982.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AHW47982.1};
RN   [1] {ECO:0000313|EMBL:AHW47982.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Pyo C.-W., Wang K., Shen S., Song Y., Wang R., Vu Q., Hall R.J., Eng K.,
RA   Bowman B., Ranade S., Geraghty D.E.;
RT   "Haplotype-resolved resequencing of conserved extended haploytpes
RT   associated with disease using fosmid target capture and long-read SMRT
RT   sequencing technology.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004352}.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|RuleBase:RU004238}.
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DR   EMBL; KJ657694; AHW47931.1; -; Genomic_DNA.
DR   EMBL; KJ657696; AHW47965.1; -; Genomic_DNA.
DR   EMBL; KJ657697; AHW47982.1; -; Genomic_DNA.
DR   RefSeq; NP_002110.1; NM_002119.3.
DR   AlphaFoldDB; X5CF87; -.
DR   SMR; X5CF87; -.
DR   Antibodypedia; 28851; 182 antibodies from 25 providers.
DR   DNASU; 3111; -.
DR   GeneID; 3111; -.
DR   KEGG; hsa:3111; -.
DR   UCSC; uc003ocr.4; human.
DR   CTD; 3111; -.
DR   VEuPathDB; HostDB:ENSG00000204252; -.
DR   HOGENOM; CLU_069380_0_0_1; -.
DR   OMA; QFAHEFD; -.
DR   OrthoDB; 4118190at2759; -.
DR   BioGRID-ORCS; 3111; 17 hits in 1140 CRISPR screens.
DR   GenomeRNAi; 3111; -.
DR   ExpressionAtlas; X5CF87; baseline and differential.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
DR   GO; GO:0045580; P:regulation of T cell differentiation; IEA:Ensembl.
DR   CDD; cd21004; IgC1_MHC_II_alpha_HLA_DO; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   PANTHER; PTHR19944:SF44; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..250
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014316165"
FT   TRANSMEM        222..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          113..193
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   250 AA;  27599 MW;  FA9482197A02AC85 CRC64;
     MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH EFDEEQLFSV
     DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV ERSNRSRAIN VPPRVTVLPK
     SRVELGQPNI LICIVDNIFP PVINITWLRN GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV
     PSAEDVYDCQ VEHWGLDAPL LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII
     MGTYVSSVPR
//
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