ID X5CF87_HUMAN Unreviewed; 250 AA.
AC X5CF87;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AHW47982.1};
GN Name=HLA-DOA {ECO:0000313|EMBL:AHW47982.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AHW47982.1};
RN [1] {ECO:0000313|EMBL:AHW47982.1}
RP NUCLEOTIDE SEQUENCE.
RA Pyo C.-W., Wang K., Shen S., Song Y., Wang R., Vu Q., Hall R.J., Eng K.,
RA Bowman B., Ranade S., Geraghty D.E.;
RT "Haplotype-resolved resequencing of conserved extended haploytpes
RT associated with disease using fosmid target capture and long-read SMRT
RT sequencing technology.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004352}.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|RuleBase:RU004238}.
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DR EMBL; KJ657694; AHW47931.1; -; Genomic_DNA.
DR EMBL; KJ657696; AHW47965.1; -; Genomic_DNA.
DR EMBL; KJ657697; AHW47982.1; -; Genomic_DNA.
DR RefSeq; NP_002110.1; NM_002119.3.
DR AlphaFoldDB; X5CF87; -.
DR SMR; X5CF87; -.
DR Antibodypedia; 28851; 182 antibodies from 25 providers.
DR DNASU; 3111; -.
DR GeneID; 3111; -.
DR KEGG; hsa:3111; -.
DR UCSC; uc003ocr.4; human.
DR CTD; 3111; -.
DR VEuPathDB; HostDB:ENSG00000204252; -.
DR HOGENOM; CLU_069380_0_0_1; -.
DR OMA; QFAHEFD; -.
DR OrthoDB; 4118190at2759; -.
DR BioGRID-ORCS; 3111; 17 hits in 1140 CRISPR screens.
DR GenomeRNAi; 3111; -.
DR ExpressionAtlas; X5CF87; baseline and differential.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
DR GO; GO:0045580; P:regulation of T cell differentiation; IEA:Ensembl.
DR CDD; cd21004; IgC1_MHC_II_alpha_HLA_DO; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF44; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..250
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014316165"
FT TRANSMEM 222..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..193
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 250 AA; 27599 MW; FA9482197A02AC85 CRC64;
MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH EFDEEQLFSV
DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV ERSNRSRAIN VPPRVTVLPK
SRVELGQPNI LICIVDNIFP PVINITWLRN GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV
PSAEDVYDCQ VEHWGLDAPL LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII
MGTYVSSVPR
//