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Database: UniProt
Entry: X5D2N5_CAPCA
LinkDB: X5D2N5_CAPCA
Original site: X5D2N5_CAPCA 
ID   X5D2N5_CAPCA            Unreviewed;       177 AA.
AC   X5D2N5;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052};
DE   AltName: Full=Testis-determining factor {ECO:0000256|ARBA:ARBA00032498};
DE   Flags: Fragment;
GN   Name=Sry {ECO:0000313|EMBL:AHW46969.1};
OS   Capreolus capreolus (European roe deer) (Cervus capreolus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC   Odocoileinae; Capreolus.
OX   NCBI_TaxID=9858 {ECO:0000313|EMBL:AHW46969.1};
RN   [1] {ECO:0000313|EMBL:AHW46969.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24697866; DOI=10.1111/mec.12745;
RA   Matosiuk M., Borkowska A., Swislocka M., Mirski P., Borowski Z.,
RA   Krysiuk K., Danilkin A.A., Zvychaynaya E.Y., Saveljev A.P., Ratkiewicz M.;
RT   "Unexpected population genetic structure of European roe deer in Poland: an
RT   invasion of the mtDNA genome from Siberian roe deer.";
RL   Mol. Ecol. 23:2559-2572(2014).
CC   -!- FUNCTION: Transcriptional regulator that controls a genetic switch in
CC       male development. It is necessary and sufficient for initiating male
CC       sex determination by directing the development of supporting cell
CC       precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
CC       Involved in different aspects of gene regulation including promoter
CC       activation or repression. Binds to the DNA consensus sequence 5'-
CC       [AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation
CC       in the minor groove and promotes DNA bending. Also involved in pre-mRNA
CC       splicing (By similarity). In male adult brain involved in the
CC       maintenance of motor functions of dopaminergic neurons.
CC       {ECO:0000256|ARBA:ARBA00025418}.
CC   -!- SUBUNIT: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-
CC       O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its
CC       DNA-binding activity. The interaction with KPNB1 is sensitive to
CC       dissociation by Ran in the GTP-bound form. Interaction with PARP1
CC       impaired its DNA-binding activity. {ECO:0000256|ARBA:ARBA00024048}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC   -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998}.
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DR   EMBL; KJ558345; AHW46969.1; -; Genomic_DNA.
DR   AlphaFoldDB; X5D2N5; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030238; P:male sex determination; IEA:InterPro.
DR   GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR   CDD; cd22028; HMG-box_SoxA_SoxB_SoxG; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR017253; SRY.
DR   PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR   PANTHER; PTHR10270:SF107; TRANSCRIPTION FACTOR SOX-14; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PIRSF; PIRSF037653; SRY; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Sexual differentiation {ECO:0000256|ARBA:ARBA00022928};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          36..104
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        36..104
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AHW46969.1"
FT   NON_TER         177
FT                   /evidence="ECO:0000313|EMBL:AHW46969.1"
SQ   SEQUENCE   177 AA;  20805 MW;  1BD382B4D1F86ACC CRC64;
     NPLAFVKASS LFTDNRSAND QCETGENVRE SGQDRVKRPM NAFIVWSRER RRKVALENPK
     MQNSEISKQL GYEWKRLTDA EKRPFFEEAQ RLLAIHRDKY PGYKYRPRRK TKRQQKLLPA
     DSSILCKQMH VETLQPFTYR DGCAKTKCSR MESQLSLSQS VTITNSFLQK EHQSSWT
//
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