ID X5D2N5_CAPCA Unreviewed; 177 AA.
AC X5D2N5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052};
DE AltName: Full=Testis-determining factor {ECO:0000256|ARBA:ARBA00032498};
DE Flags: Fragment;
GN Name=Sry {ECO:0000313|EMBL:AHW46969.1};
OS Capreolus capreolus (European roe deer) (Cervus capreolus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Odocoileinae; Capreolus.
OX NCBI_TaxID=9858 {ECO:0000313|EMBL:AHW46969.1};
RN [1] {ECO:0000313|EMBL:AHW46969.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24697866; DOI=10.1111/mec.12745;
RA Matosiuk M., Borkowska A., Swislocka M., Mirski P., Borowski Z.,
RA Krysiuk K., Danilkin A.A., Zvychaynaya E.Y., Saveljev A.P., Ratkiewicz M.;
RT "Unexpected population genetic structure of European roe deer in Poland: an
RT invasion of the mtDNA genome from Siberian roe deer.";
RL Mol. Ecol. 23:2559-2572(2014).
CC -!- FUNCTION: Transcriptional regulator that controls a genetic switch in
CC male development. It is necessary and sufficient for initiating male
CC sex determination by directing the development of supporting cell
CC precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
CC Involved in different aspects of gene regulation including promoter
CC activation or repression. Binds to the DNA consensus sequence 5'-
CC [AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation
CC in the minor groove and promotes DNA bending. Also involved in pre-mRNA
CC splicing (By similarity). In male adult brain involved in the
CC maintenance of motor functions of dopaminergic neurons.
CC {ECO:0000256|ARBA:ARBA00025418}.
CC -!- SUBUNIT: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-
CC O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its
CC DNA-binding activity. The interaction with KPNB1 is sensitive to
CC dissociation by Ran in the GTP-bound form. Interaction with PARP1
CC impaired its DNA-binding activity. {ECO:0000256|ARBA:ARBA00024048}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998}.
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DR EMBL; KJ558345; AHW46969.1; -; Genomic_DNA.
DR AlphaFoldDB; X5D2N5; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030238; P:male sex determination; IEA:InterPro.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR CDD; cd22028; HMG-box_SoxA_SoxB_SoxG; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017253; SRY.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR10270:SF107; TRANSCRIPTION FACTOR SOX-14; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF037653; SRY; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Sexual differentiation {ECO:0000256|ARBA:ARBA00022928};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 36..104
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 36..104
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHW46969.1"
FT NON_TER 177
FT /evidence="ECO:0000313|EMBL:AHW46969.1"
SQ SEQUENCE 177 AA; 20805 MW; 1BD382B4D1F86ACC CRC64;
NPLAFVKASS LFTDNRSAND QCETGENVRE SGQDRVKRPM NAFIVWSRER RRKVALENPK
MQNSEISKQL GYEWKRLTDA EKRPFFEEAQ RLLAIHRDKY PGYKYRPRRK TKRQQKLLPA
DSSILCKQMH VETLQPFTYR DGCAKTKCSR MESQLSLSQS VTITNSFLQK EHQSSWT
//