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Database: UniProt
Entry: X5HJF0_9RICK
LinkDB: X5HJF0_9RICK
Original site: X5HJF0_9RICK 
ID   X5HJF0_9RICK            Unreviewed;       536 AA.
AC   X5HJF0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-SEP-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AHX11204.1};
GN   ORFNames=NHE_0242 {ECO:0000313|EMBL:AHX11204.1};
OS   Neorickettsia helminthoeca str. Oregon.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Neorickettsia.
OX   NCBI_TaxID=1286528 {ECO:0000313|EMBL:AHX11204.1, ECO:0000313|Proteomes:UP000023755};
RN   [1] {ECO:0000313|EMBL:AHX11204.1, ECO:0000313|Proteomes:UP000023755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oregon {ECO:0000313|EMBL:AHX11204.1,
RC   ECO:0000313|Proteomes:UP000023755};
RA   Lin M., Daugherty S.C., Nagaraj S., Cheng Z., Xiong Q., Lin F.-Y.,
RA   Sengamalay N., Ott S., Godinez A., Tallon L.J., Sadzewicz L.,
RA   Fraser C.M., Dunning Hotopp J.C., Rikihisa Y.;
RT   "Sequencing and Comparison of Genomes and Transcriptome Profiles of
RT   Human Ehrlichiosis Agents.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007481; AHX11204.1; -; Genomic_DNA.
DR   EnsemblBacteria; AHX11204; AHX11204; NHE_0242.
DR   KEGG; nhm:NHE_0242; -.
DR   KO; K02313; -.
DR   Proteomes; UP000023755; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000023755};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023755}.
FT   DOMAIN      232    420       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      445    514       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     240    247       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   536 AA;  60834 MW;  6CBB1949B3BD413A CRC64;
     MSIINNRFIS AFLDAFPVPK KKVFEPVRNT DAYLDNDSLG ISAAGSVASE TKIFDTINVS
     PAPVLDSKLV EGKITDCEKW ERITGKLRKF YGEKIYRSWL KFLTFVKVEN TQLVLSVPTG
     FIREWIMVNY SDNILEFFRI EDRSVSSLEI LIREEKYKEN GNKSLQVNAP SVHIKSDEES
     VNSSNKSGLA DNLSSSLDWN RTFDNFVVGK PNELAFTASK RVAEAAELPI PGSNPLFLYG
     GVGLGKTHLM HAIVWHIKEH YKNRRVIYLS AEKFMYKYIT ALRNKDMMSF KQIFRSVDVL
     MVDDVQFISG KDSTQEEFFH TFNALIEQNK QLVISADRSP SDLQGVEERI QSRLSWGLVA
     DINHTTFELR VGILESKLEQ MTSRVVVPKK VIEFMARNIV SNVRELEGAL NKVIAHADIT
     GSVITVDSTK DLLADILRTN SVAVTLDNIL LKVSEYFNIK ISDLKSQRRV KDVSYARQVC
     MYLSKLLTQR SLLDIGKFLG GRDHATVIHA VKKIEVLIKH DVRVAEDIKI LTKRLT
//
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