ID X5K182_STRAG Unreviewed; 299 AA.
AC X5K182;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE AltName: Full=UDP-glucose pyrophosphorylase {ECO:0000256|RuleBase:RU361259};
GN Name=galU {ECO:0000313|EMBL:RRA62506.1};
GN Synonyms=gtaB {ECO:0000313|EMBL:SQA17639.1};
GN ORFNames=D5F95_01680 {ECO:0000313|EMBL:RRA62506.1}, NCTC8181_00587
GN {ECO:0000313|EMBL:SQA17639.1}, NCTC8185_00475
GN {ECO:0000313|EMBL:SUN13303.1}, RDF_0409 {ECO:0000313|EMBL:AKI94824.1},
GN WA04_10485 {ECO:0000313|EMBL:KLL35446.1};
OS Streptococcus agalactiae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1311 {ECO:0000313|EMBL:RRA62506.1, ECO:0000313|Proteomes:UP000272566};
RN [1] {ECO:0000313|EMBL:KLL35446.1, ECO:0000313|Proteomes:UP000035346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK-B-USS-215 {ECO:0000313|EMBL:KLL35446.1,
RC ECO:0000313|Proteomes:UP000035346};
RX PubMed=25946017;
RG DEVANI Consortium;
RA Rosini R., Campisi E., De Chiara M., Tettelin H., Rinaudo D., Toniolo C.,
RA Metruccio M., Guidotti S., Sorensen U.B., Kilian M., Ramirez M.,
RA Janulczyk R., Donati C., Grandi G., Margarit I.;
RT "Genomic analysis reveals the molecular basis for capsule loss in the group
RT B streptococcus population.";
RL PLoS ONE 10:E0125985-E0125985(2015).
RN [2] {ECO:0000313|EMBL:AKI94824.1, ECO:0000313|Proteomes:UP000035305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS1 {ECO:0000313|EMBL:AKI94824.1,
RC ECO:0000313|Proteomes:UP000035305};
RX PubMed=25941374; DOI=10.1073/pnas.1504725112;
RA Flores A.R., Galloway-Pena J., Sahasrabhojane P., Saldana M., Yao H.,
RA Su X., Ajami N.J., Holder M.E., Petrosino J.F., Thompson E.,
RA Margarit Y Ros I., Rosini R., Grandi G., Horstmann N., Teatero S.,
RA McGeer A., Fittipaldi N., Rappuoli R., Baker C.J., Shelburne S.A.;
RT "Sequence type 1 group B Streptococcus, an emerging cause of invasive
RT disease in adults, evolves by small genetic changes.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:6431-6436(2015).
RN [3] {ECO:0000313|Proteomes:UP000250200, ECO:0000313|Proteomes:UP000254076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC8181 {ECO:0000313|EMBL:SQA17639.1,
RC ECO:0000313|Proteomes:UP000250200}, and NCTC8185
RC {ECO:0000313|EMBL:SUN13303.1, ECO:0000313|Proteomes:UP000254076};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:RRA62506.1, ECO:0000313|Proteomes:UP000272566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JF4680 {ECO:0000313|EMBL:RRA62506.1,
RC ECO:0000313|Proteomes:UP000272566};
RA Rothen J.;
RT "Subspecies typing of Streptococcus agalactiae based on ribosomal subunit
RT protein mass variation by MALDI-TOF MS.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872,
CC ECO:0000256|RuleBase:RU361259};
CC -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC {ECO:0000256|ARBA:ARBA00005136}.
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890, ECO:0000256|RuleBase:RU361259}.
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DR EMBL; CP010867; AKI94824.1; -; Genomic_DNA.
DR EMBL; LBKL01000096; KLL35446.1; -; Genomic_DNA.
DR EMBL; QYTS01000021; RRA62506.1; -; Genomic_DNA.
DR EMBL; UAVB01000001; SQA17639.1; -; Genomic_DNA.
DR EMBL; UHEQ01000004; SUN13303.1; -; Genomic_DNA.
DR RefSeq; WP_000868271.1; NZ_WNJK01000011.1.
DR GeneID; 66885381; -.
DR PATRIC; fig|1311.1180.peg.409; -.
DR OMA; MHYVRQG; -.
DR UniPathway; UPA00215; -.
DR Proteomes; UP000035305; Chromosome.
DR Proteomes; UP000035346; Unassembled WGS sequence.
DR Proteomes; UP000250200; Unassembled WGS sequence.
DR Proteomes; UP000254076; Unassembled WGS sequence.
DR Proteomes; UP000272566; Unassembled WGS sequence.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR01099; galU; 1.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU361259,
KW ECO:0000313|EMBL:RRA62506.1};
KW Transferase {ECO:0000256|RuleBase:RU361259, ECO:0000313|EMBL:RRA62506.1}.
FT DOMAIN 5..267
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 299 AA; 33154 MW; 03AA540914320917 CRC64;
MKVRKAVIPA AGLGTRFLPA TKALAKEMLP IVDKPTIQFI VEEALKSGIE DILVVTGKSK
RSIEDHFDSN FELEYNLKEK GKNELLKLVD ETTGIRLHFI RQSHPRGLGD AVLQAKAFVG
NEPFVVMLGD DLMDITNNKV IPLTKQLIND FEATHASTIA VMEVPHEDVS AYGVIAPQGE
GVNGLYSVNT FVEKPSPEEA PSNLAIIGRY LLTPEIFNIL ETQKPGAGNE IQLTDAIDTL
NKTQRVFARK FTGDRYDVGD KFGFMKTSID YALQHPQVKD DLKKYIIDLG KSLEKTSKK
//
