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Database: UniProt
Entry: X5KQS7_9MYCO
LinkDB: X5KQS7_9MYCO
Original site: X5KQS7_9MYCO 
ID   X5KQS7_9MYCO            Unreviewed;       497 AA.
AC   X5KQS7;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CDO21594.1};
GN   ORFNames=BN978_02058 {ECO:0000313|EMBL:CDO21594.1};
OS   Mycobacterium mageritense DSM 44476 = CIP 104973.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1209984 {ECO:0000313|EMBL:CDO21594.1, ECO:0000313|Proteomes:UP000028867};
RN   [1] {ECO:0000313|EMBL:CDO21594.1, ECO:0000313|Proteomes:UP000028867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIP 104973 {ECO:0000313|EMBL:CDO21594.1,
RC   ECO:0000313|Proteomes:UP000028867};
RA   Croce O., Robert C., Raoult D., Drancourt M.;
RT   "Draft genome sequence of Mycobacterium margeritense.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDO21594.1, ECO:0000313|Proteomes:UP000028867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIP 104973 {ECO:0000313|EMBL:CDO21594.1,
RC   ECO:0000313|Proteomes:UP000028867};
RA   Urmite Genomes U.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDO21594.1}.
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DR   EMBL; CCBF010000001; CDO21594.1; -; Genomic_DNA.
DR   RefSeq; WP_036430540.1; NZ_CCBF010000001.1.
DR   EnsemblBacteria; CDO21594; CDO21594; BN978_02058.
DR   Proteomes; UP000028867; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028867};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028867}.
FT   DOMAIN      190    318       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      402    470       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     198    205       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   497 AA;  55941 MW;  5FF9A8E6CFED1498 CRC64;
     MTADPDPPFV AVWNTVVAEL NGDTDIPGAG HADPTVPTLT PQQRAWLKLV KPLVITEGFA
     LLSVPTPFVQ NEIERHLREP IIAALSRRLG QRVQLGVRIE DPPAEPEPET LFDAVVPDHA
     DEVDDDRDAQ NNAEESWPTY FSSPAQDTSA SDANAVNLNR RYTFDTFVIG ASNRFAHAAT
     LAIAEAPARA YNPLFIWGES GLGKTHLLHA AGNYAQRLFP GMRVKYVSTE EFTNDFINSL
     RDDRKASFKR SYRDIDILLV DDIQFIEGKE GIQEEFFHTF NTLHNANKQI VISSDRPPKQ
     LATLEDRLRT RFEWGLITDV QPPELETRIA ILRKKAQMDR LDVPDDVLEL IASSIERNIR
     ELEGALIRVT AFASLNKTRI DKSLAEVVLR DLIADATTMQ ISTAAIMAAT AEYFETTVEE
     LRGPGKTRAL AQSRQIAMYL CRELTDLSLP KIGQAFGRDH TTVMYAEKKI RGEMAERREV
     FDHVKELTTR IRQRAKR
//
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