ID X6M8R9_RETFI Unreviewed; 436 AA.
AC X6M8R9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:ETO09405.1};
DE Flags: Fragment;
GN ORFNames=RFI_27971 {ECO:0000313|EMBL:ETO09405.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO09405.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO09405.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000256|ARBA:ARBA00009613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO09405.1}.
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DR EMBL; ASPP01024084; ETO09405.1; -; Genomic_DNA.
DR AlphaFoldDB; X6M8R9; -.
DR EnsemblProtists; ETO09405; ETO09405; RFI_27971.
DR OrthoDB; 501358at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR001252; Malate_DH_AS.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23382:SF0; MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02866; Ldh_1_C; 2.
DR Pfam; PF00056; Ldh_1_N; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00068; MDH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT DOMAIN 199..270
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 274..310
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT DOMAIN 326..435
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 436
FT /evidence="ECO:0000313|EMBL:ETO09405.1"
SQ SEQUENCE 436 AA; 47980 MW; 15875FBB3909F577 CRC64;
MSTGLSKEDT ILPRNDRKTK EELNERNSAL SQIHKELQSV RKELLVSGCA LTAATFRSAA
RKYLLGVREE VDYLRQHRFA RTLIKEPLRV VITGAAGQVG YALVPLVASG QVLGLDQPLI
LTLLEIPSAL KALNGVAMEI EDGAYPLVDA VIPTTDPAVK EEGEKERERG FEKGNKKKYK
TIDSSFCCIT IFFLKYYYVD YAILVGGFPR GVGMERKDLL AKNAPIFQSM GEGLQKYAKE
TCKVLVVANP ANTNCLTCSR HATKIPRRNF AALTRLDQNR ATVQLAHKLG VPVRAVSNVA
IWGNHSNTQL HFLFLFFFDT LQNSISSFQV PDVSHAVVAV DGVQKKAEVE EKWVSGEFIP
SVQQRGKAVL EARNSSSAVS AANAIKDAIR DWHFGTPEGA HVALAVYSDG SHYGVAKDIF
FSFPVTCKNG TYTIVS
//
