ID X6MFS7_RETFI Unreviewed; 1882 AA.
AC X6MFS7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 13-SEP-2023, entry version 36.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RFI_24849 {ECO:0000313|EMBL:ETO12526.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO12526.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO12526.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO12526.1}.
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DR EMBL; ASPP01021317; ETO12526.1; -; Genomic_DNA.
DR EnsemblProtists; ETO12526; ETO12526; RFI_24849.
DR OrthoDB; 3270066at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT DOMAIN 1066..1344
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1560..1700
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 73..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1882 AA; 219406 MW; B8465464B6F8D5EB CRC64;
MNLIKKKKKK KKKFLSLNHC AILRKSRYIV IQQTSIAIYQ HNKLDSFFSL ATGMNTNNSQ
FMMSVYATKA MNRKRKKLSD NENDGNQSYQ PNSKRQKIEF KVPQLEKIVE SHEEDDQTNK
ENDLKCNLND EKKNEEKKNE EVNEDNVWKK SRKIRRQYFC ANFPTLVITP VKGRMLLSAS
SLIRFMNIDP KFIRPKIKAH THSASWRTLY VHLSKSVQIS DLEEISNRFN DIHSNQIVQN
LSKDEDDEVH FVSPKCCIFQ QSYQEEAKKK RIENKKKFLN LLAEYKYNIQ DIQRFKGLPI
VKVLMSSAED VKRILSDNNI FIGYRQVQCE IYDQNRRRPR KSFKQCRKCY GLNHIANECN
KKPVCKYCGR INHCATQCKF KKSPKKHHCV LCKGNHRSDS LICPKTKDIR QKLGISFTRR
ENEIINRKMN QINNHNQKDK TTAVSIKINP NKQVNKQAQD TDKQKLSPNQ NNSHKKESKD
KLESVNNFGV QNYNKNTNKK DNANNYSYTS YKNDDEMSAL RAEVASLKNT VEKLSMFIDR
MMPLMEQNSK FGGTHYSNNA LGNASETTDG TMDQWQNTDY HFQYLYNHYW SETGRTGILC
RRDIHSTKRL LCPHPYKFDM MGYESCWIEI SYPGQNKPLL FCSIYRNIQK YEVNSEEDRS
TFNNKAFYLR EFEKELVAAR KISDHIIIGG DWNAHHPAWL DKNVDEIGEA ILNFIISNNL
HILNTYPFDY TYFKENCSSC IDITLCSASL AGLCCNWRTD DYELDAHSDH LPITFNILAQ
WAPQHVKRQK VVTWNLSNNN WELFRQYLTK NLTIWTDTLM KTFQNSPEAL DQAVESWSQH
VVNTGKVTIG QKITWKGNKP WWSNKLQKLR KNVHQLKRNF RKYRTTENYE RYKEAARSFK
RILRCEKQIH ITKSIESLHE GNIRQMFCQF RSLNSNKIAI IPSLTILGKD GVTELIAEAD
IDKANLLANW FAQPPQPPKS SNEDDGHYEY VEDEICSVVQ MSKEVELSEY YLIDKWHQSE
ITEEEVIEAI RHVSAYKSQG PDNIHNLMLK NGGQSLINSL VLLFGWSYKI GYFPKAWKIA
NIVAIPKPDR DPTICKNYRP ISLLSCVGKL MERIITMRLT KYLNENQMLH QSQAGFQSWH
NTSELLLRIS ESIHTSFDKN GVTYAAMLDI SAAYDSVWRD GLRFKMRHEF KLHGRLYWWI
DSFLSERVGQ VVLNGISSSI YNFDTGVPQG SSLSPLLFLL YINDISQEVH EPIQCGMFAD
DVALWTSIYT SKMKEMDNQL QLLQQSLDGI LLWASKWKLL LSPEKSQCIT FRKKNKRNYP
LLSLHLGDAK IPETNKVKYL GLIMDSHLTY KEHVNYVYGK ASRKLGYLTF LCSYKGIRPS
MNVYNLLYKT IIRPNLEYAC AFWNGAAESH KKKLERIQRI AMCRILGVMQ SSAYDTVNII
AQVPPLELRR QQEEVKLFQR CEKYMENFPR HNLSQSYQLW KNNHQFKTDE YFCWLGKLST
LSRACINIEL AMLHGINMDH HLKPFQKIPA NCLTYIPHPI KSPFDRWSEP TPSQILSSLD
ETCVVIFTDG STMPNPGIGG VGLVIQDNSM PKWIELQIPI QGITTSIGSE IESIKTALEY
TLKYYQNKDN RVIIMNDCKF AVNAITNKWD AEMYKKQVDT CQKIMLQMGS ENVPEIYWIK
GHSGIPGNEK ADEVAKKARQ NAQSNQPGLY QRPDKSASFL NADGLGPYFT LIWNRHWTNE
GNEDNPHAHP KKFLRNLIDA QSFEKIVLHQ LEVHERRTIC RVITGKVGLN YYLHKINRAN
APECSWCGNE PETVEHFLMK CPRYNDLRMV WHSKVVDIIP ELDMKQMRMR KLVIGDRRWP
SEKRVKIVKE LARFVAATKR KL
//
