ID X6MPR6_RETFI Unreviewed; 440 AA.
AC X6MPR6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 03-MAY-2023, entry version 28.
DE SubName: Full=HECT domain and RCC1-like domain-containing protein {ECO:0000313|EMBL:ETO15671.1};
GN ORFNames=RFI_21689 {ECO:0000313|EMBL:ETO15671.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO15671.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO15671.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO15671.1}.
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DR EMBL; ASPP01018891; ETO15671.1; -; Genomic_DNA.
DR AlphaFoldDB; X6MPR6; -.
DR EnsemblProtists; ETO15671; ETO15671; RFI_21689.
DR OMA; WENKDAY; -.
DR OrthoDB; 5491782at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR043366; HECTD4.
DR PANTHER; PTHR46435; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR PANTHER; PTHR46435:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000023152};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 35..423
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 391
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 440 AA; 50883 MW; 3EB1D11D2FDF7BC4 CRC64;
MNRMKLLNKI STVGALDFAT ESNFGFGYQQ LSRVDESQLR PPKPQGTDPF VTFVLELIGQ
FVEGDTGPYR QYFSDVSSEL QSLQSYLFQL TPNGRKPQLD LLNKDKYIIR PSHPNLLLSA
TATSGNAKQG VGESLNIQSA KDSANLKEEQ FGMFEFLGKL IGMCLRTGVK LNLSLPAFVW
KPLVGLKCDR KDLYEIDTAL CKVLDEIWNY PIEKKQDFEN DFKETFMTTL SDMTLVELKP
NGSEIPVTFE NRREYVSLVY QARLNEHVPH IECIRRGIHK IVPTQILSLF TWQELERLIC
GVPDINVNLL RRHTVYDKSI DSNSEYIEWF WEILNEFSPE NKRKFIRFTW AQERLPNDDE
EFARLRLRFL IKPVIKTSAN PDQQLPKAHT CFFHLELPKY SSKEVMRERL LLAITESLSM
NADEPGRDDL NQTIQPEEVD
//
