ID X6NJF4_RETFI Unreviewed; 461 AA.
AC X6NJF4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE SubName: Full=RhoGAP domain-containing protein {ECO:0000313|EMBL:ETO25477.1};
DE Flags: Fragment;
GN ORFNames=RFI_11659 {ECO:0000313|EMBL:ETO25477.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO25477.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO25477.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO25477.1}.
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DR EMBL; ASPP01008501; ETO25477.1; -; Genomic_DNA.
DR AlphaFoldDB; X6NJF4; -.
DR EnsemblProtists; ETO25477; ETO25477; RFI_11659.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR044785; RopGAP1-5.
DR PANTHER; PTHR23177; MKIAA1688 PROTEIN; 1.
DR PANTHER; PTHR23177:SF35; RHO GTPASE-ACTIVATING PROTEIN GACA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 107..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 259..461
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETO25477.1"
SQ SEQUENCE 461 AA; 52712 MW; 167F58C292BDFDE2 CRC64;
KIETSKPKAE KDENNVGRSK SVGSAKDSFS RPLVFKSQVT FATSNDNEKQ KNEVVSPNNT
TTTNGVWASG LPPLPKTGSE EHGGLPTPVY DDEENENTND NKEVKQFFFF FFCTCFFFFF
FILFWNMIFF FCGLGREQEK RENQPKPISP VIAAINGFDF EAKKKMSLTD LNEPDYHLSS
NQIKTVPKGT PKLGKLKRLP PKQQKFQKQD NKISDVTSVE RTTQVIYDEA AGMFYGLPKE
WEELLNKQFG VSPKHLPGVK LPQYTAKIPK VLVVLKERLV EANGYQQVGI FRLAPDARDN
NAVKSSIDSG KFQLSGNDRA DVNVYANLIK VWFRDLPDPL LNCVAPERVE MANKEEDVVK
IIADFPEPQK SIFLWLCDMC VECAVHENVN KMGPKVIIVL FHFFLHFIFF NWKKKQKQNL
AIVIGPNLFN TTKFENPMKA MTYSAKVVDF FEKAIKWRQS H
//
