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Database: UniProt
Entry: X6P7R8_RETFI
LinkDB: X6P7R8_RETFI
Original site: X6P7R8_RETFI 
ID   X6P7R8_RETFI            Unreviewed;       835 AA.
AC   X6P7R8;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   07-JUN-2017, entry version 12.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=RFI_02932 {ECO:0000313|EMBL:ETO34163.1};
OS   Reticulomyxa filosa.
OC   Eukaryota; Rhizaria; Foraminifera; Monothalamids; Reticulomyxidae;
OC   Reticulomyxa.
OX   NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO34163.1, ECO:0000313|Proteomes:UP000023152};
RN   [1] {ECO:0000313|EMBL:ETO34163.1, ECO:0000313|Proteomes:UP000023152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24332546;
RA   Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA   Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA   Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT   "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL   Curr. Biol. 0:0-0(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETO34163.1}.
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DR   EMBL; ASPP01002813; ETO34163.1; -; Genomic_DNA.
DR   EnsemblProtists; ETO34163; ETO34163; RFI_02932.
DR   OMA; WTAYDAH; -.
DR   Proteomes; UP000023152; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000023152};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023152};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    407    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    439    459       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    518    535       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    571       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    616    636       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    769    794       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       51     78       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   835 AA;  95700 MW;  22D15B40B7DA6B63 CRC64;
     MWPGFRSEDM SYVQILLPSA VAEEFVDNVG REACMEFTDL NANFQPFQRT YTKDIMKIQE
     IERRIREIEA QLKEYKVPFK SDVTADDLKN CPRGTIIDAI AKDVNKTYSE LKSQGNAEKD
     LHKQLLEREA KIEVLSQMET FLSQRIALVE ERLGLMESED AMPLIRRDER RPDDVTFKYI
     AGVVTNAQRV SFERQVYLTT RGNSLVQFEA TSHDRMVFAV FFLGNQLQRL LRRLCQFMNI
     FVCYESDSET PRKVLLQQAQ SERAEDKRAH LATKKLLMRI MREAVTQLKG WKITLIQEKG
     IRVTLNKFRQ KARNNVVVAE GWCATKAKEQ IHDIMEQIVH GKGVSQPILT DCPFKGNPPT
     YFEENELTAA FQAIVDTYGV PRYKEFNPAI PTIITFPFLF GVMYGDMFHG SCLLLFALCL
     LLAGKLTDLS QSELMSSLYF ARYVLLLMGV FAVYCGVIYN DCMSVMVNGW NGSQWQHGYT
     TDDQVVMVQR NVYAVGIDPA WSGVDNQLSF ANSLKMKLAV IIGVIQMTFG LFLKLSNHLQ
     ENDFISVWFE FIPQMVFMMC FFGYMVFLIF YKWCIDWTTS TLSDTPSLIT VLIKMFLSPG
     SVDSEVQIFG NKNLQATIQV IFLLALILSI PVMLCVKPCI LRSRMANHNY QNVPDDEKEE
     TEVQLPVVQS KEGEKSEKSQ TTDEVSKQTE HEDSKDTESH HSTQHGKRHE HESFGDIMIH
     QLIHTIEYVL GTISNTASYL RLWALSLAHA ELSEVFFDKT LRMTLESTGV GAVIMNVVSA
     AAFLSFTCTV LLIMDVLECF LHALRLHWVE FQNKFFYADG KAFRPFAFEK LLKAE
//
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