ID X7VYS1_9MYCO Unreviewed; 534 AA.
AC X7VYS1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=HAMP domain protein {ECO:0000313|EMBL:ETZ75215.1};
GN ORFNames=L841_0176 {ECO:0000313|EMBL:ETZ75215.1};
OS Mycobacterium sp. MAC_080597_8934.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1335322 {ECO:0000313|EMBL:ETZ75215.1, ECO:0000313|Proteomes:UP000021997};
RN [1] {ECO:0000313|EMBL:ETZ75215.1, ECO:0000313|Proteomes:UP000021997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAC_080597_8934 {ECO:0000313|EMBL:ETZ75215.1,
RC ECO:0000313|Proteomes:UP000021997};
RA Zelazny A., Olivier K., Sampaio E.P., Holland S.M., Tallon L.J.,
RA Sadzewicz L.K., Sengamalay N., Fraser C.M., Hine E., Shefchek K.A.,
RA Das S.P., Shallom S.J., Agrawal S., Tettelin H.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETZ75215.1}.
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DR EMBL; JAOS01000001; ETZ75215.1; -; Genomic_DNA.
DR AlphaFoldDB; X7VYS1; -.
DR PATRIC; fig|1335322.3.peg.170; -.
DR Proteomes; UP000021997; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 258..310
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 342..466
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 534 AA; 57204 MW; F574CFECD3D3C4D3 CRC64;
MTTAAALPGR ISAFARWVVR TPWPLFWLSM MQADIIGALF VLGFLRYALP PEDRIQLQDL
PVVNLAVFAT SLVVLFLAAS VVNLTLLMPV FRWQRRDNLL AESDPAATEL ARIRALRMPF
YRTVTSMVIW CIGGVVFIIA SWSVARFAAP VVAVATGLGA AATAIIGYLQ CERVLRPVAV
AALRSGVPEN VKAPGVILRQ ILTWMLSTAV PVLAIVLAVV ADKTSLLHAT PEKLFTPILL
LAVAALGIGL VSTLLVAMSI ADPLRQLRWA LSEVQRGNYN AHMQIYDASE LGLLQAGFND
MVRDLSERQR LRDLFGRYVG EDVARRALER GTELGGQERD VAVLFVDLVG STQLAATRPP
AEVVHLLNEF FRVVVETVGK HGGFVNKFQG DAALAIFGAP IEHPDSPGGA LAAARELHDA
LLPVIGSAEF GIGVSAGRAI AGHIGAQARF EYTVIGDPVN EAARLTELAK LEPGHVLASA
IAVSGALDSE ALCWDVGEVV ELRGRTAPTQ LARPVKLATP EEVAPQEVSS EVSG
//
