ID X8HDV3_9FIRM Unreviewed; 1096 AA.
AC X8HDV3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:EUB26055.1};
GN ORFNames=HMPREF1504_1815 {ECO:0000313|EMBL:EUB26055.1};
OS Veillonella sp. ICM51a.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Veillonella.
OX NCBI_TaxID=936591 {ECO:0000313|EMBL:EUB26055.1, ECO:0000313|Proteomes:UP000020651};
RN [1] {ECO:0000313|EMBL:EUB26055.1, ECO:0000313|Proteomes:UP000020651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICM51a {ECO:0000313|EMBL:EUB26055.1,
RC ECO:0000313|Proteomes:UP000020651};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Haft D.H., Methe B.,
RA Sutton G., Nelson K.E.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB26055.1}.
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DR EMBL; JAPX01000029; EUB26055.1; -; Genomic_DNA.
DR RefSeq; WP_038123896.1; NZ_JAPX01000029.1.
DR AlphaFoldDB; X8HDV3; -.
DR PATRIC; fig|936591.3.peg.951; -.
DR Proteomes; UP000020651; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 563..724
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 742..899
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1096 AA; 124632 MW; 76798C69E6E400DF CRC64;
MDTSIDTLLS QNPSMTDGLK AFRQKGKSVI YGLSGSQKSF LLSCAVPEEQ VQSIIIVVHD
KEHKELWERD LAFFWPNVQV LPFPITERVE FTTVARSLEG QGAQMRALSM LAWNRPVVVL
ATIEEATQYV VSPQYVISQS VHLEVSQSIE RDELLEKLVK IGYERVDQVE QRGHFSVRGD
IFDIFPVNSD DPIRMEFFGD EIDTMRHFSV DTQRSIETVD AYTVTPFFLT SDDADSTLLS
YAKDGLIIYD EPVRIQEALK KFLKEDTTHR KQHCEWSELQ RSVDAKIEVA FTFMQQRSIG
LAGFYPIGIQ GKTMTSFERQ IPLLMDEIKQ WQKLGNQVVL VINNLQRREG IEKTLHGDAI
PYKLCESWDF EPNTVHVMQG LLTDGFELPH SHLVVVVEGN IYGQQKRKLR NKPKKGQEIN
YFTDLSVGDY VVHSMHGIGK YVGLKTIETE GIHRDYIEIA YAGTDRLYLP ASNLDQLQKY
IGNEGDVPRI HKMGGSDWRK AVTKAQKSID DLADKLVELY AKREITEGFA FLPDQPWQQE
FEDAFPYEET EDQLQATREI KESMERPTPM DRLLAGDVGF GKTEVAMRAI FKAVVSGKQV
AVLVPTTVLA QQHYQTFLNR FNPFGVKVDV LNRFRSTAEK KEVLKGVENG SIDILIGTHS
LLNKKVKFKD LGFLVVDEEQ RFGVAQKEKW KEWASNIDVL TLSATPIPRT LHMSLVGVRE
MSVISTPPED RLPVQTYVVE YDMNLIADAI KRELARGGQV YFVYNRVASI NHMGELLEQA
LPDLRYAIAH GQMTGRQIEE IMTDFYEGHY DVLLSTSIIE TGLDIPNANT IIIYDADRLG
LSQLYQMRGR VGRSRRRAYA YFMYRPDKML SEAAEKRLKA IEEFTELGAG FKLAMRDLEI
RGAGNLLGSQ QHGNIASVGF GMYVSMLEEA IAKAQNKEVV KEIVPDPAID LEIDAFIDDA
YIKDSARKIS VYQRMLQIKN KAQLDDLTDE LIDRFGTPTD PVDRLLRVAQ IKEQARLLGI
KSIVHREGQL IIHWQDDSKM ADWDMGAVRE DLWKKMKFMD TKPASLYISL NGLKGSILTI
TEAVMKELSK KSKGGL
//
