ID   X8K882_9STRE            Unreviewed;       548 AA.
AC   X8K882;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:EUC79793.1};
GN   ORFNames=HMPREF1518_2094 {ECO:0000313|EMBL:EUC79793.1};
OS   Streptococcus sp. SR1.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1161416 {ECO:0000313|EMBL:EUC79793.1, ECO:0000313|Proteomes:UP000022050};
RN   [1] {ECO:0000313|EMBL:EUC79793.1, ECO:0000313|Proteomes:UP000022050}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SR1 {ECO:0000313|EMBL:EUC79793.1,
RC   ECO:0000313|Proteomes:UP000022050};
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Haft D.H., Methe B.,
RA   Sutton G., Nelson K.E.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUC79793.1}.
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DR   EMBL; JATR01000015; EUC79793.1; -; Genomic_DNA.
DR   AlphaFoldDB; X8K882; -.
DR   PATRIC; fig|1161416.3.peg.1138; -.
DR   Proteomes; UP000022050; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR   PANTHER; PTHR42713; HISTIDINE KINASE-RELATED; 1.
DR   PANTHER; PTHR42713:SF2; TWO-COMPONENT SENSOR KINASE YESM; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF06580; His_kinase; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EUC79793.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          274..327
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
SQ   SEQUENCE   548 AA;  63028 MW;  7EF8C6A980AC17D8 CRC64;
     MKQFWLHSLL RIYSLVMIVV IASFAIMLSY ADWDSREKEA QRVAERVTTR TVSEVEYYHR
     ESTRLAQSLV ENQARIEGIY KYFSLSTPDY FYWQLERKTS PYISVSLYEN IDDLYVRNDF
     VTGVAIVLQD YKEVYVSTRE KRSGEKIPAE GFKPAANSFA IPVSDPVSDK DLGVIYISLS
     PDVLHGAIDN TRGHIPMAVT VTSPFETEMF HIGEKVSAER ENWFVGVTSH GYQVRVAVPK
     NFVLTGTLTS SAIIIGLSIL FIIILYVTLR QTFSNYQKQV VDLVDSIEVI AQGEEGLRID
     TSEKDQELLL IAETTNDMLD SLEKNIHDIY QLELSQKDAN MRALQAQINP HFMYNTLEFL
     RMYAVMQSQD ELADIIYEFS SLLRNNISDE RETTLKQELE FCRKYSYLCM VRYPKSIAYG
     FKIAPELEEM RIPKFTLQPL VENYFAHGVD HRRTDNVISI KALKGQGFVE ILVVDNGRGM
     SAEKLAALQE KLTQRSFEHE ASYSGERQSI GIVNVHERFV LYFGDRYQIS VESAEQEGVR
     YHITIQDE
//