ID XYLR_LACPE Reviewed; 388 AA.
AC P21940;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Xylose repressor;
GN Name=xylR;
OS Lactiplantibacillus pentosus (Lactobacillus pentosus).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=1589;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=MD353;
RX PubMed=1660563; DOI=10.1007/bf00290664;
RA Lokman B.C., van Santen P., Verdoes J.C., Kruese J., Leer R.J., Posno M.,
RA Pouwels P.H.;
RT "Organization and characterization of three genes involved in D-xylose
RT catabolism in Lactobacillus pentosus.";
RL Mol. Gen. Genet. 230:161-169(1991).
CC -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR EMBL; M57384; AAA25257.1; -; Genomic_DNA.
DR PIR; S18560; S18560.
DR AlphaFoldDB; P21940; -.
DR SMR; P21940; -.
DR STRING; 1589.GCA_001188985_00557; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000600; ROK.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR18964:SF177; N-ACETYLMANNOSAMINE KINASE; 1.
DR PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR Pfam; PF00480; ROK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01125; ROK; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; DNA-binding; Repressor; Transcription;
KW Transcription regulation; Xylose metabolism.
FT CHAIN 1..388
FT /note="Xylose repressor"
FT /id="PRO_0000095713"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
SQ SEQUENCE 388 AA; 43604 MW; 2CB03049F6A75412 CRC64;
MENRSISRTQ LRNRNLKLVL QQIINHPATS RIAISHELNL NKSTISSLYN SLSADHFIEE
LGEGAASNVG GRKPIMARLN KKYGYTITFD LGYRQLHAMA NYLDAEIIDY QEIDTKGRPI
EAMLDDCRHF VQEMQTQVHA IHGLLGICFS IHGIINDNQI VHSPWIDMHD IDIVKQFKAE
FDVPVILENE ANLSAIYERD FNAGLDYRNS ITLSIHRGIG AGIILDKHLF RGKQGEAGEV
GRSLTLLGPN TAGQSVESIC SEEAIINRVK RIKQDETTNR QTVVQLYQQH DREVERILSQ
SCSVIAGLIY NVVTTLNPDA IFINSELLAE TPELLGDIQD NYRDIAQDQL PITLTKNTQF
ATSLGGCSLI THYVLGMVDY ELQFKEAD
//
