ID Y108_MYCPN Reviewed; 404 AA.
AC P75561;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Uncharacterized adenine-specific methylase MPN_108;
DE EC=2.1.1.72;
GN OrderedLocusNames=MPN_108; ORFNames=C09_orf404, MP046;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
OS (Mycoplasmoides pneumoniae).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae;
OC Mycoplasmoides.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129 / Subtype 1;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000305}.
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DR EMBL; U00089; AAB95694.1; -; Genomic_DNA.
DR PIR; S73372; S73372.
DR RefSeq; NP_109796.1; NC_000912.1.
DR RefSeq; WP_010874465.1; NZ_OU342337.1.
DR AlphaFoldDB; P75561; -.
DR IntAct; P75561; 1.
DR STRING; 272634.MPN_108; -.
DR REBASE; 152958; M2.Ssp60837ORF1696P.
DR EnsemblBacteria; AAB95694; AAB95694; MPN_108.
DR KEGG; mpn:MPN_108; -.
DR PATRIC; fig|272634.6.peg.114; -.
DR HOGENOM; CLU_650238_0_0_14; -.
DR OrthoDB; 9800643at2; -.
DR BioCyc; MPNE272634:G1GJ3-184-MONOMER; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF07669; Eco57I; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..404
FT /note="Uncharacterized adenine-specific methylase MPN_108"
FT /id="PRO_0000088016"
SQ SEQUENCE 404 AA; 47115 MW; D096EEF4E1CD6895 CRC64;
MSQNGDKDHE LIQGKVKSKT EIEDSVILDQ DTLQGKGEEK TKLDELIRWE AEKNDLLKLI
DNVGNDEVFT TVETCQRMLD DLFPQDHEVW SNPDLKWLNP CDKNGVFFRE IALRLDKGLA
KVIPDEYERK KHIMTKMLFS IDLTKFTSLM VRRTLYYCIK ANKRKTSEDE GCAIANGAWF
NNECGNVVKP YKEHYFDKQG KNKKCKFCRT DEKFKYQQSS SNEKYAYDFI HLNPNEYESY
FKTNFGVMKF DVIIGNPPYQ LANNRGGDAG DGNGANPIFQ EFILRALELQ PKYLAMIVPA
RWINSSEKVF LKFRAKLQKS NGFKGINIFF DSKHCFPNRQ IKGGVCYFNW QNGYEGQTLI
TTKSSKKGKQ EEIETYKRDF FAPVLNNTEQ VIFRKKFDTT FIKR
//
