ID Y1760_DROME Reviewed; 1093 AA.
AC Q9VKA4; E1JHG5; Q8MT43;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 3.
DT 24-JAN-2024, entry version 137.
DE RecName: Full=Probable G-protein coupled receptor CG31760;
GN ORFNames=CG31760;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=Isoform C is produced by readthrough of a stop codon between
CC the codons for Val-875 and Arg-877. This is likely to be a rare event
CC with most transcripts using the stop codon following Val-875.
CC {ECO:0000305};
CC Name=C {ECO:0000312|FlyBase:FBgn0051760};
CC IsoId=Q9VKA4-3; Sequence=Displayed;
CC Name=B {ECO:0000312|FlyBase:FBgn0051760}; Synonyms=D
CC {ECO:0000312|FlyBase:FBgn0051760};
CC IsoId=Q9VKA4-2; Sequence=VSP_058136;
CC -!- MISCELLANEOUS: This protein is translated by readthrough of a stop
CC codon. Readthrough of the terminator codon TAG occurs between the
CC codons for Val-875 and Arg-877. There is currently no sequence that
CC provides the identity of residue 876. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; AE014134; AAF53174.3; -; Genomic_DNA.
DR EMBL; AE014134; ACZ94248.1; -; Genomic_DNA.
DR EMBL; AE014134; AGB92937.1; -; Genomic_DNA.
DR EMBL; AY118394; AAM48423.1; -; mRNA.
DR RefSeq; NP_001162962.1; NM_001169491.2.
DR RefSeq; NP_001260402.1; NM_001273473.2.
DR RefSeq; NP_723730.2; NM_164996.3. [Q9VKA4-3]
DR BioGRID; 60692; 1.
DR IntAct; Q9VKA4; 2.
DR STRING; 7227.FBpp0304318; -.
DR TCDB; 9.A.14.15.2; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q9VKA4; 4 sites.
DR iPTMnet; Q9VKA4; -.
DR PaxDb; 7227-FBpp0290241; -.
DR DNASU; 34642; -.
DR EnsemblMetazoa; FBtr0331996; FBpp0304318; FBgn0051760. [Q9VKA4-3]
DR GeneID; 34642; -.
DR KEGG; dme:Dmel_CG31760; -.
DR UCSC; CG31760-RA; d. melanogaster. [Q9VKA4-3]
DR AGR; FB:FBgn0051760; -.
DR FlyBase; FBgn0051760; CG31760.
DR VEuPathDB; VectorBase:FBgn0051760; -.
DR eggNOG; KOG4418; Eukaryota.
DR InParanoid; Q9VKA4; -.
DR OMA; AIEFNFH; -.
DR OrthoDB; 3430189at2759; -.
DR BioGRID-ORCS; 34642; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 34642; -.
DR PRO; PR:Q9VKA4; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0051760; Expressed in brain and 7 other cell types or tissues.
DR Genevisible; Q9VKA4; DM.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF16; G-PROTEIN COUPLED RECEPTOR CG31760-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..1093
FT /note="Probable G-protein coupled receptor CG31760"
FT /id="PRO_0000372663"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..512
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 534..547
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 548..568
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 569..584
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 585..607
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 608..619
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..660
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 661..681
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 682..701
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 702..722
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 723..730
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 731..751
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 752..1093
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 847..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 519
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 877..1093
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_058136"
SQ SEQUENCE 1093 AA; 121584 MW; 342587FD4C2B18C9 CRC64;
MKCWHNVVRR RRKKPTAAAA AKGSKGSHGG VASPRDEDAI CQRQQQVDTY TWLTTQAVPL
LWLHLLLLVA FAKHAAAATT IATNPEATTT TVSNYTVTTT ALSSSTTTTS SGSAPALSSA
ADKFAGNWAN LEDSFRNIVR IGDGNTVTRT SIEQSLVTIH DIATENLGTL CISTLYRPLQ
VPINSERYES SRQKTDLAAS ILQEVGIIRH GGLSDALAKG LLTDDFITGA RILALNLTNG
AVQSYVWWVK GTAAEIQRYD EDGLQIGKKP AGSYPWFDDE TSSPTLRSPK FAPSPPNNYY
KGWWTYPYFS CSQSRWLVSY SIAIPPIGRH GLRGFISIDI DVSTLRVNQC EAEPYPFGSR
RQKMQQLQTH NRLGARRSLF LGSRMGAIDE STINDLQAFH SSHKCHRTSM VCDYRQPSAE
TPTVTGGKLL TTLTGSSSWT RGSYQCLCRG GFYSLRHPDG FNGTIMEIAW QEQQDNISNY
YSEVFKCLPC APGCDTCTGP EPCLANYHWP FRISLLTISI GCACGTFVLA GYLFRHRRVK
VFKVASPIFL MITLIGCAIM YLEMVAIFPY LDTTWCIATK WTRHMGFCIT YTSLLMKTWR
VSLTYRVKSA HKIKLNDQQL LQWMVPILLV MLIYLGTWTI SATPTAEVIL DQSQLKFKQC
SYNWWDHSLA IGEVFFLAWG IRVCYNVRNA ESLYNEARLI SYAIYNIALV NIAMVVFHVM
LFPNAGPDYK YMLGFVRTQL STTTTIALVF GPKILRVFKG QGDKWDQKAK VRSITASFSL
NGVGLVPEES PDLYQENEEL KEQVQKLAHQ IEFMKTVHMQ MNNRHLKPKP GGYFTITSTS
FQAPYSKNTV STAQTQTGKD ENSTPTKLKS PKGKVXRGQR SVKDCSIEID GGQGRTTLVE
DAIEFNFHLA DTEKGLIVQE DERPGSDEEE AALIAQFRRL FAPILDDSLN LYYQLNDLDD
TEHVRIHQTV AQMNDLTSSE EETMVTQVNS PSPPPVGVEL LLPISSDSST ASSSLYAIHT
PSPAHPSGVL LMPQNLESPL LSGSDAITIT EQVELHNPPH HLQLLEDENN TSCSLSSNLT
DSKTLDGRTP IVV
//
