ID Y1931_DICDI Reviewed; 1211 AA.
AC Q54T82;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Putative leucine-rich repeat-containing protein DDB_G0281931;
GN ORFNames=DDB_G0281931;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AAFI02000043; EAL66525.1; -; Genomic_DNA.
DR RefSeq; XP_640507.1; XM_635415.1.
DR AlphaFoldDB; Q54T82; -.
DR SMR; Q54T82; -.
DR PaxDb; 44689-DDB0267071; -.
DR EnsemblProtists; EAL66525; EAL66525; DDB_G0281931.
DR GeneID; 8623322; -.
DR KEGG; ddi:DDB_G0281931; -.
DR dictyBase; DDB_G0281931; -.
DR eggNOG; ENOG502QU7G; Eukaryota.
DR HOGENOM; CLU_269759_0_0_1; -.
DR InParanoid; Q54T82; -.
DR OMA; YRKSVYW; -.
DR PRO; PR:Q54T82; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48053; LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED; 1.
DR PANTHER; PTHR48053:SF164; OS02G0232500 PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 3.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
PE 4: Predicted;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1211
FT /note="Putative leucine-rich repeat-containing protein
FT DDB_G0281931"
FT /id="PRO_0000393413"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 728..750
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 771..791
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 818..838
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 876..896
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 920..942
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 947..967
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 980..1000
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1012..1032
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 154..176
FT /note="LRR 1"
FT REPEAT 179..201
FT /note="LRR 2"
FT REPEAT 203..225
FT /note="LRR 3"
FT REPEAT 227..249
FT /note="LRR 4"
FT REPEAT 251..273
FT /note="LRR 5"
FT REPEAT 275..297
FT /note="LRR 6"
FT REPEAT 299..321
FT /note="LRR 7"
FT REPEAT 323..345
FT /note="LRR 8"
FT REPEAT 346..367
FT /note="LRR 9"
FT REPEAT 370..392
FT /note="LRR 10"
FT REPEAT 394..415
FT /note="LRR 11"
FT REPEAT 418..440
FT /note="LRR 12"
FT REPEAT 445..465
FT /note="LRR 13"
FT REPEAT 477..499
FT /note="LRR 14"
FT REPEAT 501..524
FT /note="LRR 15"
FT REGION 1109..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 137953 MW; 60C44DC2CEEFB5E9 CRC64;
MNKKFIFILL IVFICFLNIS QSIRINNNKN NNINNNYNNN NNNNIQTKEK RERNLIKFKE
IEKIRKFLGN VESLTTIPLV SNEKIILEKL YSDWNGKDWD DNTNWLNGDP CMNQWYGIEC
NSFDGGITNN VISIKMSLNN IVGEMSTEIK NLVHLQTLDI SNNGFYGEIP IGIFQQMNNL
SYISLNENEF QGDLEWASYL PDSIVTLWIA MNQFQGTIPT FFSKYPILDL LFLEENLLIG
TIPPEVGDLK KIKLLDFGLN TITGTLPSSI GNLSYLEQFW LYDNQLEGSI PLTMGNLQNL
KLFEVTRNQL GGDLSGVFLN NPNLKSLRFS GNSFYGDLDW ICQLDGLRDV HFDINRFESL
PNCLGKAPLQ MNELLLADNL ISGTIPSSIG NMIGIEYINL ARNNLTGTIP SSFNNFSNLN
RIDISSNKFN CSLSEILDPI KHQTHLTIIS AQYNEIHGEF FENMVWDGVQ QIELLTKIFI
INLSHNKLSG PIPEYLSWMP NLNDLDLSYN NLSGTVPNQL SFLSTMYLEN NPFLGSSDGS
LPLFMEPSVI FIHKDTESYA CPSIIGKGFD IRISLDSTYY NNSFCLCDYN YRGVNGSCKI
CPQDSYCPGG GNDILIPSGY YPMPSNENPE YLLKCIISNF GYTSCNPDSS YNYTCQDGYQ
GRLCSKCVDG YFHKGTECSV CPTGPQSIVI FIVVVVVFIA LFLFFVMTDP KRSLPSSTRK
TVMYYYQVFN LLLSKLSPWP SFFSIFYSGS SWLNFSFGFL CINNLSRWPN LFIVMICLPF
AFLVISIVFI ASMQLFHYVK SSLNGVDYIF NKKLIYSGVR VNLLALNFLY LPLCIYIFQN
YPCTKDQVTG ESFMSFFPWQ ECGDNSTHNR IMRLTIAFTI IYVIGIPLLF AILLFYNRKR
LDNPMILTMI GSIYIDYRKS VYWYELVALG RRFFMAVSLA LIDPKSSFSI FVVLLVIGSS
IISQIIFKPY VYRISNYSET IGNSVLLFSY VCILILSSLA TTKLYDSQGI EIILSVVVVV
YTVLLLLLFL FSLKYFLPKK WQTVIDYHII KFITWVRITS NNLISDIKDI NSIDGDDSFE
TTKEPIFERT VSNNLNVLGS FELKRRNSQI NSNCNNNNNN NNNNNNNNNN NNNNNNNNIN
NNIISAKQLD CNNNNNNYNG EKITPGDGQD CLISLSIDNS GTNFNHNNDN NNNDDNNDNN
INNNEEFNKN N
//
