ID Y5547_DICDI Reviewed; 335 AA.
AC Q8MXL9; Q553B5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=PA-phosphatase related-family protein DDB_G0275547;
GN ORFNames=DDB_G0275547;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69524.1; -; Genomic_DNA.
DR RefSeq; XP_643505.1; XM_638413.1.
DR AlphaFoldDB; Q8MXL9; -.
DR STRING; 44689.Q8MXL9; -.
DR PaxDb; 44689-DDB0232325; -.
DR EnsemblProtists; EAL69524; EAL69524; DDB_G0275547.
DR GeneID; 8620086; -.
DR KEGG; ddi:DDB_G0275547; -.
DR dictyBase; DDB_G0275547; -.
DR eggNOG; KOG3030; Eukaryota.
DR HOGENOM; CLU_757429_0_0_1; -.
DR InParanoid; Q8MXL9; -.
DR OMA; WFSYRRY; -.
DR PhylomeDB; Q8MXL9; -.
DR Reactome; R-DDI-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-DDI-419408; Lysosphingolipid and LPA receptors.
DR Reactome; R-DDI-428157; Sphingolipid metabolism.
DR PRO; PR:Q8MXL9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR CDD; cd03390; PAP2_containing_1_like; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR PANTHER; PTHR10165; LIPID PHOSPHATE PHOSPHATASE; 1.
DR PANTHER; PTHR10165:SF108; PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0271516-RELATED; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..335
FT /note="PA-phosphatase related-family protein DDB_G0275547"
FT /id="PRO_0000367485"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 335 AA; 37750 MW; BD6854EFD3719FCA CRC64;
MDRNFLNESN NSTNNRNKYV IYDEEESKPL FYNYDFRKKN KMVMYLFDWM MVVILLIVGG
ILFLKVTVRG RLFTLDDESI SYPKLPELVP MHVLIPVIIA LPLAIIIVVS LIVKRDCHDF
HHAILGLAQS LALTLLLTGS FKCFIGGLRP NFLEVCDPTP ASIAAGNPPV GFSKIYYDRS
ICSADDSIVN DALSAYPSGH SSITAASFGF LALFIHAKFK IFDNRGHIFL YVIVSGCIIG
AGLIGISRVA DYRHTFLNVL AGWSIGLIIA LSCYRLNYSS LFGRDNHVSI HSHWLTYWNH
HDNLNNNNNN IKNNFDLEKN CNQSPNNIAL DELNK
//
