ID Y7754_DICDI Reviewed; 462 AA.
AC Q55GA0;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0267754;
GN ORFNames=DDB_G0267754;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73330.1; -; Genomic_DNA.
DR RefSeq; XP_647284.1; XM_642192.1.
DR AlphaFoldDB; Q55GA0; -.
DR SMR; Q55GA0; -.
DR STRING; 44689.Q55GA0; -.
DR PaxDb; 44689-DDB0189521; -.
DR EnsemblProtists; EAL73330; EAL73330; DDB_G0267754.
DR GeneID; 8616090; -.
DR KEGG; ddi:DDB_G0267754; -.
DR dictyBase; DDB_G0267754; -.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_040980_0_0_1; -.
DR InParanoid; Q55GA0; -.
DR OMA; DSWSLQF; -.
DR PhylomeDB; Q55GA0; -.
DR PRO; PR:Q55GA0; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF156; TNF RECEPTOR-ASSOCIATED FACTOR FAMILY PROTEIN DDB_G0267744-RELATED; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 2.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..462
FT /note="TNF receptor-associated factor family protein
FT DDB_G0267754"
FT /id="PRO_0000393758"
FT DOMAIN 326..449
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT ZN_FING 24..62
FT /note="RING-type; degenerate"
FT ZN_FING 150..217
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 214..273
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT REGION 104..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 53475 MW; D7F9DE76C9A5782A CRC64;
MTSLISITLD ELLINEDIND DYTCCVCECL LIEALQCRNG HVACKNCFIK IVKSKKECMT
CRCEIKSIES LSKNRYLEKE IRKLNINCPN SFLKRELNLN NNNKNGNGNE GSSANEIEQP
QQPQQQQPQE LIKDINNGCK EILTIDQLDS HLKQCEYRFL KCTNLYANDL CSELDICGYD
YRYNQSEKHR DECPYGIIGC TLCGKDCSRV DIESHTENHC PKLLVKCPTC NQDQLIARCD
LDDHLSVDCA MIEIDCILKE SGCKERVKRN QLANHLSSDN HLLFINNQFN QQNDIINQLK
LELSHCNDLN EILTAKLDRY NNDNTMFRGK WVISNWTDKL NQYPPKKYLS LDFNLSQNKP
FSIRVYPNGS SVMWHNCTIS LVKLYQTEST IKFSFEIENE DPLKNDLQTK TDIFKGLNDS
WSLQFFKVCD QANNNGFIIN DTLTINFSIK IKKCFENIFI TE
//