ID Y924_HELPY Reviewed; 68 AA.
AC O25581;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 121.
DE RecName: Full=Probable tautomerase HP_0924;
DE EC=5.3.2.-;
GN OrderedLocusNames=HP_0924;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- SIMILARITY: Belongs to the 4-oxalocrotonate tautomerase family.
CC {ECO:0000305}.
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DR EMBL; AE000511; AAD07977.1; -; Genomic_DNA.
DR PIR; D64635; D64635.
DR RefSeq; NP_207716.1; NC_000915.1.
DR RefSeq; WP_001115881.1; NC_018939.1.
DR PDB; 2ORM; X-ray; 2.10 A; A/B/C/D/E/F=2-68.
DR PDB; 3M21; X-ray; 1.90 A; A/B/C/D/E/F=2-68.
DR PDBsum; 2ORM; -.
DR PDBsum; 3M21; -.
DR AlphaFoldDB; O25581; -.
DR SMR; O25581; -.
DR DIP; DIP-3525N; -.
DR IntAct; O25581; 6.
DR MINT; O25581; -.
DR STRING; 85962.HP_0924; -.
DR PaxDb; 85962-C694_04755; -.
DR EnsemblBacteria; AAD07977; AAD07977; HP_0924.
DR KEGG; hpy:HP_0924; -.
DR PATRIC; fig|85962.47.peg.989; -.
DR eggNOG; COG1942; Bacteria.
DR InParanoid; O25581; -.
DR OrthoDB; 9799841at2; -.
DR PhylomeDB; O25581; -.
DR EvolutionaryTrace; O25581; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006725; P:cellular aromatic compound metabolic process; IEA:InterPro.
DR CDD; cd00491; 4Oxalocrotonate_Tautomerase; 1.
DR Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR InterPro; IPR018191; 4-OT.
DR InterPro; IPR004370; 4-OT-like_dom.
DR InterPro; IPR014347; Tautomerase/MIF_sf.
DR NCBIfam; TIGR00013; taut; 1.
DR PANTHER; PTHR35530:SF1; TAUTOMERASE BSL7456-RELATED; 1.
DR PANTHER; PTHR35530; TAUTOMERASE-RELATED; 1.
DR Pfam; PF01361; Tautomerase; 1.
DR SUPFAM; SSF55331; Tautomerase/MIF; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Isomerase; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..68
FT /note="Probable tautomerase HP_0924"
FT /id="PRO_0000209531"
FT ACT_SITE 2
FT /note="Proton acceptor; via imino nitrogen"
FT /evidence="ECO:0000250"
FT STRAND 3..8
FT /evidence="ECO:0007829|PDB:3M21"
FT HELIX 17..35
FT /evidence="ECO:0007829|PDB:3M21"
FT HELIX 39..41
FT /evidence="ECO:0007829|PDB:3M21"
FT STRAND 43..48
FT /evidence="ECO:0007829|PDB:3M21"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:3M21"
FT STRAND 54..56
FT /evidence="ECO:0007829|PDB:3M21"
FT HELIX 61..65
FT /evidence="ECO:0007829|PDB:3M21"
SQ SEQUENCE 68 AA; 7512 MW; AFAD98CCA757587F CRC64;
MPFINIKLVP ENGGPTNEQK QQLIEGVSDL MVKVLNKNKA SIVVIIDEVD SNNYGLGGES
VHHLRQKN
//
