ID YC8E_SCHPO Reviewed; 321 AA.
AC O94601;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=Uncharacterized protein C622.14;
GN ORFNames=SPCC622.14;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: GTPase-activating protein for the ADP ribosylation factor
CC family. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA21870.2; -; Genomic_DNA.
DR PIR; T41494; T41494.
DR RefSeq; NP_588186.2; NM_001023176.3.
DR AlphaFoldDB; O94601; -.
DR SMR; O94601; -.
DR BioGRID; 275752; 14.
DR STRING; 284812.O94601; -.
DR iPTMnet; O94601; -.
DR MaxQB; O94601; -.
DR PaxDb; 4896-SPCC622-14-1; -.
DR EnsemblFungi; SPCC622.14.1; SPCC622.14.1:pep; SPCC622.14.
DR GeneID; 2539181; -.
DR KEGG; spo:SPCC622.14; -.
DR PomBase; SPCC622.14; -.
DR VEuPathDB; FungiDB:SPCC622.14; -.
DR eggNOG; KOG0704; Eukaryota.
DR HOGENOM; CLU_044516_2_0_1; -.
DR InParanoid; O94601; -.
DR OMA; QDENHKC; -.
DR PhylomeDB; O94601; -.
DR Reactome; R-SPO-6807878; COPI-mediated anterograde transport.
DR Reactome; R-SPO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:O94601; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:GOC.
DR GO; GO:0005096; F:GTPase activator activity; ISO:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048205; P:COPI coating of Golgi vesicle; IBA:GO_Central.
DR CDD; cd08830; ArfGap_ArfGap1; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR46395; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR46395:SF1; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW Cytoplasm; GTPase activation; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..321
FT /note="Uncharacterized protein C622.14"
FT /id="PRO_0000318102"
FT DOMAIN 2..119
FT /note="Arf-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT ZN_FING 17..40
FT /note="C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REGION 160..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 321 AA; 35518 MW; B0E79DB6A2AA180D CRC64;
MSYKLDQLTR LPENKKCFDC DAPNPQWASC NLGIFICLDC SGQHRGLGVE KSFVRSITMD
NWSERQVKMM EVGGNSNAKT FLSTDPMFSA AGSIREKYNT DIAEDLRQKI RAEVDGVEWV
KVDRPKSVSS HASVTSSSTV PTIPSVSKEA NDKYFAKLGS INSQRPDDLP PSQGGRYQGF
GSSNSVNPNS SARNNGGSFL DQLSSNPVSA LSHGWNMFSR SVSQQIQDVN KSYIQPGITK
VQDPETRKDY MNAINNFSSN VQEGAKQSFT QLKSFLDENV YSENPQNTRG TYDAEIDSPY
SALAASPPPE DYSKKNFDKH D
//
