ID YF64_CAEEL Reviewed; 413 AA.
AC Q21890; Q0G823; Q8T8M5; Q8T8M6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 3.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=Uncharacterized protein R102.4;
GN ORFNames=R102.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=b;
CC IsoId=Q21890-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q21890-2; Sequence=VSP_011905;
CC Name=c;
CC IsoId=Q21890-3; Sequence=VSP_028794;
CC -!- SIMILARITY: Belongs to the threonine aldolase family. {ECO:0000305}.
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DR EMBL; Z70309; CAB54291.3; -; Genomic_DNA.
DR EMBL; Z70309; CAB54293.3; -; Genomic_DNA.
DR EMBL; Z70309; CAL36512.2; -; Genomic_DNA.
DR PIR; D88817; D88817.
DR PIR; T24106; T24106.
DR PIR; T24108; T24108.
DR RefSeq; NP_001076701.2; NM_001083232.3. [Q21890-3]
DR RefSeq; NP_501978.3; NM_069577.4. [Q21890-2]
DR RefSeq; NP_501979.3; NM_069578.5. [Q21890-1]
DR AlphaFoldDB; Q21890; -.
DR SMR; Q21890; -.
DR BioGRID; 43062; 1.
DR STRING; 6239.R102.4b.1; -.
DR EPD; Q21890; -.
DR PaxDb; 6239-R102-4b; -.
DR EnsemblMetazoa; R102.4a.1; R102.4a.1; WBGene00011291. [Q21890-2]
DR EnsemblMetazoa; R102.4a.2; R102.4a.2; WBGene00011291. [Q21890-2]
DR EnsemblMetazoa; R102.4b.1; R102.4b.1; WBGene00011291. [Q21890-1]
DR EnsemblMetazoa; R102.4c.1; R102.4c.1; WBGene00011291. [Q21890-3]
DR GeneID; 177961; -.
DR KEGG; cel:CELE_R102.4; -.
DR UCSC; R102.4b; c. elegans. [Q21890-1]
DR AGR; WB:WBGene00011291; -.
DR WormBase; R102.4a; CE41252; WBGene00011291; -. [Q21890-2]
DR WormBase; R102.4b; CE41253; WBGene00011291; -. [Q21890-1]
DR WormBase; R102.4c; CE41254; WBGene00011291; -. [Q21890-3]
DR eggNOG; KOG1368; Eukaryota.
DR GeneTree; ENSGT00390000014681; -.
DR InParanoid; Q21890; -.
DR OMA; MRQTGFM; -.
DR OrthoDB; 178754at2759; -.
DR PhylomeDB; Q21890; -.
DR PRO; PR:Q21890; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00011291; Expressed in material anatomical entity and 5 other cell types or tissues.
DR ExpressionAtlas; Q21890; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008732; F:L-allo-threonine aldolase activity; IBA:GO_Central.
DR GO; GO:0006545; P:glycine biosynthetic process; IBA:GO_Central.
DR GO; GO:0006567; P:threonine catabolic process; IBA:GO_Central.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Lyase; Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..413
FT /note="Uncharacterized protein R102.4"
FT /id="PRO_0000121579"
FT MOD_RES 265
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..30
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_028794"
FT VAR_SEQ 1..20
FT /note="MISRHFTVLTALNLQTKIKI -> MYSLLTRRVIVLGNV (in isoform
FT a)"
FT /evidence="ECO:0000305"
FT /id="VSP_011905"
SQ SEQUENCE 413 AA; 45756 MW; 78BFC48C673FB1F5 CRC64;
MISRHFTVLT ALNLQTKIKI CIRNFSIRGA MTKVNGNSNG NGISASTDLL DTPSAYTQKS
NKTHTSIDLR SDTVTVPSVE MRRAMAEAIV GDDVYGEDTT TNRLEQRCAE LFGKEAGLFV
TSGTMGNLLA IMAHCQRGEE IIVGRYNHIH RWEQGNYAQF AGISATTLEV KPDGTMDLND
IEQAIRVKDC HMPASKLICI ENTHNYTGGK ALPIEWMRSV KQLAERRDLK VHMDGARIYN
AAVASNCSVS KIASFADTVQ MCFSKGLGAP VGSIVVGPKD FIDRARHSRK ALGGGWRQSG
ILAAAAHIAL DHADATIRAD HERAKTLARM INDATPEEFR TKVFAAEKDI TNMVLVHCQN
GVTVQQLTDF FQKHDILAMT FDARRIRMVL NWNVSDENLE TIVEVYKKFL KQL
//
