ID YIDC_CLOTE Reviewed; 220 AA.
AC Q899S4;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Membrane protein insertase YidC;
DE AltName: Full=Foldase YidC;
DE AltName: Full=Membrane integrase YidC;
DE AltName: Full=Membrane protein YidC;
GN Name=yidC; OrderedLocusNames=CTC_00096;
OS Clostridium tetani (strain Massachusetts / E88).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=212717;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88;
RX PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000305}.
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DR EMBL; AE015927; AAO34748.1; -; Genomic_DNA.
DR RefSeq; WP_011098420.1; NC_004557.1.
DR AlphaFoldDB; Q899S4; -.
DR SMR; Q899S4; -.
DR STRING; 212717.CTC_00096; -.
DR GeneID; 24254455; -.
DR KEGG; ctc:CTC_00096; -.
DR HOGENOM; CLU_036138_4_2_9; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000001412; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..220
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124779"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..194
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 220 AA; 24985 MW; 17E6430BB783DB04 CRC64;
MSHLNNALVE FFVIIHKFIS SIITNPNYSY GVAIIFVTLI IKLILLPLNI KSMRSTIRIN
EIQPEIQKIQ KKYKNDPQRL QQEQMKLYKE YNINPFGSCL PLLLQWPILI ALYYVFNNIQ
GISGVSFLWV KDLASPDIVL AVLAGATQYY SGLLMNPKGD NTQAKTASNM NLSMSIMMIF
ISSRLKAALV IYWVTGNLIQ MGQTILTKKL EQKHSANKDA
//
