ID Z4YJD9_MOUSE Unreviewed; 487 AA.
AC Z4YJD9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Keratin 12 {ECO:0000313|Ensembl:ENSMUSP00000017741.4};
GN Name=Krt12 {ECO:0000313|Ensembl:ENSMUSP00000017741.4,
GN ECO:0000313|MGI:MGI:96687};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000017741.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000017741.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000017741.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000017741.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000017741.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; NP_034791.2; NM_010661.2.
DR AlphaFoldDB; Z4YJD9; -.
DR SMR; Z4YJD9; -.
DR ProteomicsDB; 318300; -.
DR Antibodypedia; 55294; 269 antibodies from 33 providers.
DR DNASU; 268482; -.
DR Ensembl; ENSMUST00000017741.4; ENSMUSP00000017741.4; ENSMUSG00000020912.5.
DR GeneID; 268482; -.
DR KEGG; mmu:268482; -.
DR UCSC; uc007lis.1; mouse.
DR AGR; MGI:96687; -.
DR CTD; 3859; -.
DR MGI; MGI:96687; Krt12.
DR VEuPathDB; HostDB:ENSMUSG00000020912; -.
DR GeneTree; ENSGT00940000159382; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR OMA; EHQNADH; -.
DR OrthoDB; 4640531at2759; -.
DR PhylomeDB; Z4YJD9; -.
DR BioGRID-ORCS; 268482; 2 hits in 77 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000020912; Expressed in substantia propria of cornea and 53 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0061303; P:cornea development in camera-type eye; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF369; KERATIN, TYPE I CYTOSKELETAL 12; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Proteomics identification {ECO:0007829|EPD:Z4YJD9,
KW ECO:0007829|MaxQB:Z4YJD9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 119..433
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 428..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 123..196
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 225..259
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 331..408
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 433..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 52563 MW; 76F18921899DDA85 CRC64;
MSLSVCTSAL SRRSSSQNGA AGRPWGASAS SVAGGYGGSA SGFGVGCGGL FSAASMFGSS
SGFSGGSAGC LPGLGSAYGG PLRGGAGGMG IGMGIAGSSG GGSLCIFSGN DGGLLSGSEK
ETMQNLNDRL ASYLGKVRSL EEANAELENK IREWYETRRT RDAGSQSDYS KYYPLIEDLK
NKIVSARVSN AQLLLQIDNA RLAAEDFRMK YENELALRQT VEADINGLRR VLDELTLTRA
DLEAQLETLT EELAYMKKNH EEELQSFQAG GPGEVNVEMD AAPGVDLTKV LNEMRAQYEA
MAEQNRKDAE AWFLEKSREL RKEISSNTEQ LQSSKSEVTD LKRMVQNLEI ELQSQLAMKS
SLEGSLAETE GGYCCQLSQV QQLIGSLEEQ LQQVRADAER QNADHQRLLG VKARLEMEIE
TYRRLLEGDS QGDGFDESSS LSVSKPQTPS VDSSKDPNKT RKIKTVVQEI VNGEVVSSQV
QELEEEM
//
