GenomeNet

Database: UniProt
Entry: Z4YKR8_MOUSE
LinkDB: Z4YKR8_MOUSE
Original site: Z4YKR8_MOUSE 
ID   Z4YKR8_MOUSE            Unreviewed;       471 AA.
AC   Z4YKR8;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   25-OCT-2017, entry version 24.
DE   SubName: Full=Transient receptor potential cation channel subfamily V member 1 {ECO:0000313|Ensembl:ENSMUSP00000104110};
GN   Name=Trpv1 {ECO:0000313|Ensembl:ENSMUSP00000104110,
GN   ECO:0000313|MGI:MGI:1341787};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000104110, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000104110, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104110,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000104110}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104110};
RG   Ensembl;
RL   Submitted (APR-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000104110}.
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DR   EMBL; AL663116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; Z4YKR8; -.
DR   SMR; Z4YKR8; -.
DR   PaxDb; Z4YKR8; -.
DR   Ensembl; ENSMUST00000108470; ENSMUSP00000104110; ENSMUSG00000005952.
DR   MGI; MGI:1341787; Trpv1.
DR   eggNOG; KOG3676; Eukaryota.
DR   eggNOG; ENOG4110DG4; LUCA.
DR   GeneTree; ENSGT00550000074425; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000005952; -.
DR   ExpressionAtlas; Z4YKR8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097603; F:temperature-gated ion channel activity; IEA:Ensembl.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0050968; P:detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050960; P:detection of temperature stimulus involved in thermoception; IEA:Ensembl.
DR   GO; GO:0002024; P:diet induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0002790; P:peptide secretion; IEA:Ensembl.
DR   GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR   GO; GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.
DR   GO; GO:0009268; P:response to pH; IEA:Ensembl.
DR   GO; GO:0050954; P:sensory perception of mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0060083; P:smooth muscle contraction involved in micturition; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR024863; TRPV1.
DR   InterPro; IPR008347; TRPV1-4_channel.
DR   PANTHER; PTHR10582; PTHR10582; 2.
DR   PANTHER; PTHR10582:SF17; PTHR10582:SF17; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01768; TRPVRECEPTOR.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     66     85       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    105    123       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    144    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    170    189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    314       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       68    326       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   471 AA;  54349 MW;  9A01D059872C002B CRC64;
     MYNEILILGA KLHPTLKLEE LTNKKGLTPL ALAASSGKIG NRHDMLLVEP LNRLLQDKWD
     RFVKRIFYFN FFVYCLYMII FTTAAYYRPV EGLPPYKLNN TVGDYFRVTG EILSVSGGVY
     FFFRGIQYFL QRRPSLKSLF VDSYSEILFF VQSLFMLVSV VLYFSHRKEY VASMVFSLAM
     GWTNMLYYTR GFQQMGIYAV MIEKMILRDL CRFMFVYLVF LFGFSTAVVT LIEDGKNNSL
     PVESPPHKCR GSACRPGNSY NSLYSTCLEL FKFTIGMGDL EFTENYDFKA VFIILLLAYV
     ILTYILLLNM LIALMGETVN KIAQESKNIW KLQRAITILD TEKSFLKCMR KAFRSGKLLQ
     VGFTPDGKDD FRWCFRVDEV NWTTWNTNVG IINEDPGNCE GVKRTLSFSL RSGRVSGRNW
     KNFALVPLLR DASTRDRHST QPEEVQLKHY TGSLKPEDAE VFKDSMAPGE K
//
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