ID ZIP12_ARATH Reviewed; 355 AA.
AC Q9FIS2;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE RecName: Full=Probable zinc transporter 12;
DE AltName: Full=ZRT/IRT-like protein 12;
DE Flags: Precursor;
GN Name=ZIP12; OrderedLocusNames=At5g62160; ORFNames=MTG10.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=26306426; DOI=10.1111/tpj.12996;
RA Inaba S., Kurata R., Kobayashi M., Yamagishi Y., Mori I., Ogata Y.,
RA Fukao Y.;
RT "Identification of putative target genes of bZIP19, a transcription factor
RT essential for Arabidopsis adaptation to Zn deficiency in roots.";
RL Plant J. 84:323-334(2015).
CC -!- FUNCTION: Zinc transporter involved in zinc uptake in roots. Targeted
CC by BZIP23 transcription factor in response to zinc-deficient
CC conditions. {ECO:0000269|PubMed:26306426}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: By zinc-deficiency. {ECO:0000269|PubMed:26306426}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AF369914; AAL38437.1; -; Genomic_DNA.
DR EMBL; AB016880; BAB10178.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97571.1; -; Genomic_DNA.
DR RefSeq; NP_201022.1; NM_125609.2.
DR AlphaFoldDB; Q9FIS2; -.
DR SMR; Q9FIS2; -.
DR STRING; 3702.Q9FIS2; -.
DR PaxDb; 3702-AT5G62160-1; -.
DR EnsemblPlants; AT5G62160.1; AT5G62160.1; AT5G62160.
DR GeneID; 836336; -.
DR Gramene; AT5G62160.1; AT5G62160.1; AT5G62160.
DR KEGG; ath:AT5G62160; -.
DR Araport; AT5G62160; -.
DR TAIR; AT5G62160; ZIP12.
DR eggNOG; KOG1558; Eukaryota.
DR HOGENOM; CLU_027089_3_0_1; -.
DR InParanoid; Q9FIS2; -.
DR OMA; PLWCFRQ; -.
DR OrthoDB; 1112460at2759; -.
DR PhylomeDB; Q9FIS2; -.
DR PRO; PR:Q9FIS2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIS2; baseline and differential.
DR Genevisible; Q9FIS2; AT.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IMP:UniProtKB.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR004698; Zn/Fe_permease_fun/pln.
DR NCBIfam; TIGR00820; zip; 1.
DR PANTHER; PTHR11040:SF164; ZINC TRANSPORTER 12-RELATED; 1.
DR PANTHER; PTHR11040; ZINC/IRON TRANSPORTER; 1.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..355
FT /note="Probable zinc transporter 12"
FT /id="PRO_0000041649"
FT TOPO_DOM 26..50
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..231
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 156..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 37571 MW; D86C0E9E172F3C66 CRC64;
MSRFRKTLVS AFVLCLVIFP LLVSAAEEEN QCGGSKGGSA AEKASALKYK IIAFFSILIA
GVFGVCLPIF GLKTESNFFM YVKAFAAGVI LATGFVHILP DATESLTSSC LGEEPPWGDF
PMTGLVAMAA SILTMLIESF ASGYLNRSRL AKEGKTLPVS TGGEEEHAHT GSAHTHASQG
HSHGSLLIPQ DDDHIDMRKK IVTQILELGI VVHSVIIGIS LGASPSVSTI KPLIAAITFH
QLFEGFGLGG CISEAKFRVK KIWVMLMFFA LTAPIGIGIG IGVAEIYNEN SPMALKVSGF
LNATASGILI YMALVDLVAP LFMNQKTQSS MKIQVACSVS LVVGAGLMSL LAIWA
//
