ID ZSWM7_DANRE Reviewed; 140 AA.
AC A4FVI0; A2ASQ5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Zinc finger SWIM domain-containing protein 7;
GN Name=zswim7; ORFNames=si:ch211-31p3.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=WIK; TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in early stages of the homologous recombination
CC repair (HRR) pathway of double-stranded DNA breaks arising during DNA
CC replication or induced by DNA-damaging agents. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SWS1 family. {ECO:0000305}.
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DR EMBL; AL928675; CAM14449.1; -; Genomic_DNA.
DR EMBL; BX510960; CAM14449.1; JOINED; Genomic_DNA.
DR EMBL; BC133904; AAI33905.1; -; mRNA.
DR RefSeq; NP_001077009.1; NM_001083540.1.
DR AlphaFoldDB; A4FVI0; -.
DR STRING; 7955.ENSDARP00000114854; -.
DR PaxDb; 7955-ENSDARP00000114854; -.
DR GeneID; 325530; -.
DR KEGG; dre:325530; -.
DR AGR; ZFIN:ZDB-GENE-030131-4255; -.
DR CTD; 125150; -.
DR ZFIN; ZDB-GENE-030131-4255; zswim7.
DR eggNOG; ENOG502RZB5; Eukaryota.
DR HOGENOM; CLU_132858_2_0_1; -.
DR InParanoid; A4FVI0; -.
DR OMA; CFASCHY; -.
DR OrthoDB; 5151at2759; -.
DR PhylomeDB; A4FVI0; -.
DR TreeFam; TF339438; -.
DR PRO; PR:A4FVI0; -.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000067608; Expressed in tail and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0097196; C:Shu complex; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR InterPro; IPR007527; Znf_SWIM.
DR PANTHER; PTHR28498; ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7; 1.
DR PANTHER; PTHR28498:SF1; ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7; 1.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA recombination; DNA repair; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..140
FT /note="Zinc finger SWIM domain-containing protein 7"
FT /id="PRO_0000307405"
FT ZN_FING 76..114
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT CONFLICT 110
FT /note="I -> V (in Ref. 2; AAI33905)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="A -> P (in Ref. 2; AAI33905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 140 AA; 15441 MW; 454CA3A20635ABEC CRC64;
MGSSLVSVAE QLLKDLQRTY SEIKQIPDDL LIALRFVFGP CALQALDLVD QHSVTCVSSP
SGRKAFQVLG GSGRLYTCFT SCHYCPCPAF SFTVLRRNES LMCKHLLAVI LSQAMGLCQQ
EQVSDQQMTH ILSRQPEAST
//
