ID   ACPX_STRRM              Reviewed;          95 AA.
AC   P43677;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   24-NOV-2009, entry version 57.
DE   RecName: Full=Oxytetracycline polyketide synthase acyl carrier protein;
DE            Short=ACP;
OS   Streptomyces rimosus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1927;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=94215879; PubMed=8163168; DOI=10.1016/0378-1119(94)90144-9;
RA   Kim E.S., Bibb M.J., Butler M.J., Hopwood D.A., Sherman D.H.;
RT   "Sequences of the oxytetracycline polyketide synthase-encoding otc
RT   genes from Streptomyces rimosus.";
RL   Gene 141:141-142(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=15883;
RA   Linton K.J., Hunter I.S.;
RT   "The acyl-carrier protein for biosynthesis of oxytetracycline from
RT   Streptomyces rimosus: overexpression in Escherichia coli, purification
RT   and characterization of the apoprotein.";
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acyl carrier protein.
CC   -!- PATHWAY: Antibiotic biosynthesis; oxytetracycline biosynthesis.
CC   -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific
CC       serine of the apo-ACP-like protein (Potential).
CC   -!- SIMILARITY: Contains 1 acyl carrier domain.
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DR   EMBL; Z25538; CAA80986.1; -; Genomic_DNA.
DR   EMBL; U01666; AAA03334.1; -; Genomic_DNA.
DR   PDB; 1NQ4; NMR; -; A=1-95.
DR   PDBsum; 1NQ4; -.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   Pfam; PF00550; PP-binding; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic biosynthesis; Phosphopantetheine.
FT   CHAIN         1     95       Oxytetracycline polyketide synthase acyl
FT                                carrier protein.
FT                                /FTId=PRO_0000180253.
FT   MOD_RES      41     41       O-(pantetheine 4'-phosphoryl)serine
FT                                (Probable).
FT   HELIX         6     17
FT   STRAND       30     32
FT   HELIX        34     37
FT   HELIX        42     54
FT   HELIX        63     66
FT   HELIX        70     83
SQ   SEQUENCE   95 AA;  9916 MW;  D0C92084807BB244 CRC64;
     MTLLTLSDLL TLLRECAGEE ESIDLGGDVE DVAFDALGYD SLALLNTVGR IERDYGVQLG
     DDAVEKATTP RALIEMTNAS LTGASPSAGG AARDK
//