ID   O07944_STRPR            Unreviewed;      4848 AA.
AC   O07944;
DT   01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT   01-JUL-1997, sequence version 1.
DT   19-JAN-2010, entry version 58.
DE   SubName: Full=Pristinamycin I synthase 3 and 4;
GN   Name=snbDE;
OS   Streptomyces pristinaespiralis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=38300;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SP92;
RA   de Crecy-Lagard V.A., Saurin W., Thibaut D., Gil P., Naudin L.,
RA   Crouzet J., Blanc V.;
RT   "Streptogramin B biosynthesis in Streptomyces pristinaespiralis and
RT   Streptomyces virginiae: molecular characterization of the last
RT   structural peptide synthase gene.";
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SP92;
RX   MEDLINE=97158664; PubMed=9006024;
RA   de Crecy-Lagard V., Blanc V., Gil P., Naudin L., Lorenzon S.,
RA   Famechon A., Bamas-Jacques N., Crouzet J., Thibaut D.;
RT   "Pristinamycin I biosynthesis in Streptomyces pristinaespiralis:
RT   molecular characterization of the first two structural peptide
RT   synthetase genes.";
RL   J. Bacteriol. 179:705-713(1997).
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DR   EMBL; X98690; CAA67249.1; -; Genomic_DNA.
DR   EMBL; Y11548; CAA72312.1; -; Genomic_DNA.
DR   PIR; T30289; T30289.
DR   HSSP; O30409; 1DNY.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 4.
DR   PROSITE; PS50075; ACP_DOMAIN; 4.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE   4: Predicted;
KW   Phosphopantetheine.
SQ   SEQUENCE   4848 AA;  522087 MW;  E17591617A2B9A0E CRC64;
     MTRSGLADVL PLSPLQEGLL FQVTYGAETH GPDVYTVQMV FELRGPLDED GLRAAAAALL
     RRHPNLRAGF WQQGVERPVQ FVPNEVPLPW HTRDFTALGE SDRERAVEAY VTADRAERFD
     PGAPPLIRFA LLGLAADHHK LVLTTHHLLL DGWSMPLLVR ELFTLYGQRG DDAGMPPVTP
     YRAYLAHLAG RDDDAARAAW RTALADLEEP SLVAGAGAGR GAADGSALPG QIWHEIDAAT
     TAGLTALARS CNITLQHPGA KRLGTAARPQ LGRDDVVFGA TVAHRPPEIP GIESTIGMFI
     NTLPVRVRVR PAETLGDLLG RVQREQAALI EHRHLSLTDI RSTTGTGELF DTVVVFENYP
     LDPAVLRAEA RGLRLAGFEV SDATHYPLSL LAIPGESLRF RLDHRGDVLD EAGARLLLER
     LDTLLTDIAE HGADLPVGRL DLLSAAERHQ VLEEFNDTGL PAEDATLAAL FEAQAARTPD
     TTALLVGGRS LTYAELNARA NRLARHLVTL GAGPEQIVAV KLERSLDLYV ALLAVLKTGA
     AYLPVDTAYP AERIAFMMDD ARPAVVLTGE DTGQDLSGYD DTDLTDADRT APLLPAHPAY
     VIYTSGSTGT PKAVVMPGAA LVNLLAWHRR EIPGEAGAPV AQFTTIGFDV AAQEILATWL
     HGKTLAVPSQ EVRRSAEQLA AWLDEQHVSE LYAPNLVIEA LAEAAAEAGR TLPALRHIAQ
     AGEALTLTRT VREFAAAVPG RQLHNHYGPA ETHVMTGTAL PEDPAAWSEH APLGRPVSGA
     RVYVLDSALR PVAPGVTGEL YLAGAGVSRG YLNRPVLTAE RFVADPYAPS PGARMYRTGD
     LGRWNTRGEL EFAGRADHQV KIRGFRIEPG EIEAALTDLP AVARAAVVVR EDRPGDKRLV
     AYAVPAGEGL DAAAVRSRLA RTLPDFMVPA AIVALDALPL TPNGKLDRAA LPAPQSTTAV
     QRTPRSPREE ILTTLFAAVL KLPRVGIDDN FFDLGGHSLL ATRLISRIRT VLGAEITLRD
     LFEAPTVAGL GERLDQASGA RPALTPAERP ERLPLSHAQR RLWFLGRLDG PNSTYNIPLA
     LRLSGTLDTA ALRAALADLV ARHETLRTRY PSHDGEPYQH IVAPADATPA LTVVHTEEHR
     LAEQLAEATA RPYDLTTELP LRATLFRLGE DEHVLLLLLH HIAGDGWSLA PLTRDLAAAY
     AARRDGHAPG FAPLPVQYAD YTLWQRGLLG DADDPTSLQA AQLAHWRQAL EGRPAHLELP
     CDHPRPAVAT HRGATVPFHI DAGLHEKLTA LAKACDSSLF MVLQAAFAAL LTRHGAGTDI
     PVGSPVAGRT DDALDDLVGF FVNTLVLRTD TSGDPTFREL VARVRQFDLA AYTHQDMPFE
     KLVEEVNPER SLARNPLFQV VLALQSMPAA DLALPGLDVA AEPVRVGFAK FDLGLAVIEE
     HTADGTRAGI RGDWEYSTEL FERGTVEALG SRLVRLLDAV ADDPERTIGS VDLLDATERH
     RLLVGLNTTD GPLPEERTLT ALFEQQAAAT PDATALVMGD RSLTYAELDA RANRLARHLV
     ALGAGPEQIV ALQLPRSLDL VTAVLAVWKS GAAYLPVDPD YPPERIAHMR ADARPALVVD
     AIPDDTTLAA YADSRLTDAD RSAPLLPAHP AYVIYTSGST GAPKGVVVAH RSLAATVPAQ
     AAAFGLGTHS RVLNFASISF DAAVWELTSA LFTGAGLVLA DADDLLPGPS LARLVHDRHI
     TLIALPPSAL PALPDGALPP GTDLIVAGDA TAPDQAARFA PGRRMVNAYG LTETTVCATM
     SEPATGDGAP PIGRPVAHAR VYVLDERLRP VPPGVTGEMY VSGAGVARGY LHRPALTAQR
     FVPDPYALLF GETGTRMYRT GDLARLDADG RLHFAGRADQ QVKIRGFRIE PGEIETVLTA
     HPAVAAGAVI AREDTPGDKQ LVAYLTRDTT HHAAPDQDLG TGQVDRWQQT YDSLYEAEPG
     RAFGEDFSGW NSSYTAEEIP LEEMREWRAA TVDRVLALRP RRVLEIGCGT GLILSQVAPH
     TEEYRGTDLS RSVVARLAAH LAGRPDLADK VTVDARAAHE TDDLPKGRFD TIVLNSVAQY
     FPDARYLAGI LHRAAELLAP GGTIFLGDIR NLRTLHAFRT AVELRRAGPF ADPAAVRRAV
     EQSLATEKEL LLDPDFFTDL VDRDPHLTRA DITLRTAAHH NEMSRHRYDV TLHRGGDSPA
     PAETVLRWGT DLDTAGELAR VLSGPRPVRV TGIPNARLTG ETRAAQALER GSAADACARL
     EAPAPAGALD PHDVYALGAV CTWGHDDDTF DAYAGDGTAY RPRTGRQGPL ANDPARAEQD
     AALVGELRDL VAQRLPAHMA PAAYVLLDRL PLSANGKLDR DALPAPDRGE DAAGQAPRTR
     REEILSTLFA EVLGLPAVGI DRSFFDLGGH SLLATRLLSR IRSVLGAELA VRDLFQAPTV
     AALAERVDGA QEARPPLTAR TRPAEVPLSF AQYRLWFLHR MEGPGPTYNI PMSLRLTGTL
     DTAALRAALA DVTARHEALR TVYPESGGVP RQHVLHDVRP HFETADTTAQ TLEADLTRAA
     RRGFDLAREL PLRATLFRLA EDEHVLLLLM HHIAGDGWSW PPLARDLGDA YAARLAGRAP
     DLPPLPVQYA DYALWQRDLL GDEDDPTSRH ARQLAYWAGA LDDLPEELQL PCDRPRPAVA
     THRGDTVPFA VDPDLHQRLN ALATEGRASL FMVLQAAFAA LLTRHGAGTD IPLGSPIAGR
     TDDALEDLVG FFVNTLVLRT DTSGDPTFRE LLQRVRESDL AAYAHQDVPF EKLVEKLRPE
     RSLSRHPLFQ VMLAFQNSGE ARLALPGLDA RALPVGVGVA KFDLHLSMVE LRTGDGRPGG
     IQAALEYATD LFDRTTAQAL VDRLLRLLAA VADDPGLTVG RVELLDPAER HRVLQDWNTT
     PGGDGAARTP VTELLERQAA RTPDAVALVH DDGRLTYAEL HARANRLARH LITLGAGPEQ
     IVALRMPRSL DLYVALLAVL KTGAAYLPVD ISYPAERIAF MIEDARPVTV LDRLPDDLGA
     YRDTDLTDAD RTAPLRPEHP AYVIHTSGST GTPKAVVMPH AGLANLLTWH ARRFPGGTGV
     RTAQFTAIGF DFSVQEILSP LVMGKTLAVP SEEVRHSAEL LAGWLETQQI NELFAPNLVI
     EALAEAAAEA GRTLPDLTDI LQGGEALAPT ERVRAFTAAV PGRRLHNVYG PAETHAVTTH
     TLAADPAHWP PSAPIGRPVD HDRVYVLDSA LRPVPPGVTG ELYLAGAGVA RGYLHRPRTT
     AERFVADPYA PRPGARMYRT GDLGRWNTRG ELEFAGRADH QVKIRGFRVE PGEVEAALTA
     HPRITQAAVL AHGDRLVAYV VTTADRDLTG VREHLAARLP DFMVPTAYVR LEALPLTVNG
     KLDRAALPAP DAPAAGRAPR TVREEILCGL FAEVLGTERA GIDDNFFDLG GHSLLATRLI
     SRIRTALGAE ITLRDLFEAP TVAGLGERLD QASGARPALT PAERPERLPL SYAQRRLWFL
     GRLTGGDPGY NMPVGLRLSG TLDTAALTAA LADLVARHET LRTVFPEGDD GSPHQLVLDP
     GAARPALHPR DTTQDDLATE LAAAARHCFD LTTELPLRAT LFRLAEDEHV LLLLLHHIAG
     DGWSLAPLAR DLVTAYAARR DGHAPDFAPL PVQYADYTLW QHALLGDEND PDSTISRQSA
     HWKDALAGLP EEIQLPADRP RPATPAHRGE AVFRTLDADL HRELLHLART GGASLFMVLQ
     AAVAAVLTRH GAGTDIPLGS PIAGRTDDAL DDLVGFFVNT LVLRTDTSGN PTFRELLDRV
     REFDLAAYAH QDVPFEKLVE DAAPGRSLSR HPLFQVLLAL QNTPEAVLEL PGLTARPEVV
     TLGAAKFDLT FNLAERHGPD GEPHGIDAVL EYSTDLFDRT TAEALTDRLI TFLRAVAADP
     GRTVADVPIL DADDHARVLT GWNDTDHPRG RRTADACLPR RIAEQAARTP HAVAVTEAGG
     TLITYSELDA RANRLARHLI RRGVTAETRV AVLAERSAQL VVTTLAILKA GGVYVPLHTG
     YPVDRMRHVL ADTEAALLLT DTHHAATAAR LDTPALTVDE DTTAGEQDTT APDVTVRPDQ
     LAYIMFTSGS TGTPKGIGIT HRDAIALAAD RCWDLDTGSR VLMHSPYAFD ISTFELFAPL
     LAGGRIVVAP RGDIDAAVLQ RTLAAHGVTS LLLTAGLLGV IADEAPEVFT GVKDVWTGGD
     VVSPTAVRRV LEACPGTVVK TLYGPTETTL GCTWLPFTDP RRIPPAVPIG RPLDNTRAYV
     LDERLRPVPP GVTGELYIAG AGLARGYWDQ SARTAERFTA DPHAHLFGDT GGRMYRTGDL
     ARRDADGVLH FCGRADQQVK IRGFRIEPGE IETALAAHPD VTRAAVVARP GRAGDKVLVA
     YLVTAPDAGD TTAEQLRAGL ETQLPDYMVP AAFVALPALP VTPNGKLDRD ALPEPDWGGG
     AGRPPRGPRE EILCGLFAEV LGAPRVGTDD NFFELGGHSM LATRLVGRVK TVLGADIGVR
     TLFEAPTVAA LAARIDGADT GHDPFGVVLP LRTGGSRAPL FCVHPAGGFG WVYSALLRHT
     DREQPLYALQ ARGLARPEPL PDDIDAMARD YAEQIRKTVP EGPYEILGWS FGGLVAHAVA
     ARLQAEGAEV SLLAVLDGYP DAYDGTEHEV GEEQVLAILL NAAGVDRAQA FGDAPLQRAA
     VLEKLRDSGS ALGNLDDDAV GRMVTVFLNN TRLIQNFRPR RFTGDMVFFA AAAGHHDPAL
     TPGNWRPYVT GRIEEHHLDT DHAGLARPEA LGAVARTLAQ RDTPQAGH
//