ID   O52550_AMYMD            Unreviewed;       441 AA.
AC   O52550;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   19-JAN-2010, entry version 31.
DE   SubName: Full=RifH;
GN   Name=rifH;
OS   Amycolatopsis mediterranei (Nocardia mediterranei).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=33910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S699;
RX   MEDLINE=98174059; PubMed=9512878; DOI=10.1016/S1074-5521(98)90141-7;
RA   August P.R., Tang L., Yoon Y.J., Ning S., Muller R., Yu T.W.,
RA   Taylor M., Hoffmann D., Kim C.G., Zhang X., Hutchinson C.R.,
RA   Floss H.G.;
RT   "Biosynthesis of the ansamycin antibiotic rifamycin: deductions from
RT   the molecular analysis of the rif biosynthetic gene cluster of
RT   Amycolatopsis mediterranei S699.";
RL   Chem. Biol. 5:69-79(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S699;
RX   MEDLINE=98165773; PubMed=9497318; DOI=10.1074/jbc.273.11.6030;
RA   Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G.;
RT   "3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the
RT   formation of the precursor of mC7N units in rifamycin and related
RT   antibiotics.";
RL   J. Biol. Chem. 273:6030-6040(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S699;
RX   MEDLINE=21201076; PubMed=11278540; DOI=10.1074/jbc.M009667200;
RA   Yu T.W., Muller R., Muller M., Zhang X., Draeger G., Kim C.G.,
RA   Leistner E., Floss H.G.;
RT   "Mutational analysis and reconstituted expression of the biosynthetic
RT   genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the
RT   starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei
RT   S699.";
RL   J. Biol. Chem. 276:12546-12555(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S699;
RA   Yu T.-W., Pogosova-Agadjanyan E.L., Kuan L.-Y., Bai L., Tin A.M.,
RA   Adman E., Floss H.G.;
RT   "Rifamycin insusceptibility: exploring the rif gene cluster of
RT   Amycolatopsis mediterranei S699.";
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S699;
RA   Yu T., August P.R., Tang L., Yoon Y.J., Ning S., Mueller R.,
RA   Taylor M., Kim C., Zhang X., Pogosova-Agadjanyan E.L., Tin A.M.,
RA   Hutchinson C.R., Floss H.G.;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AF040570; AAC01718.1; -; Genomic_DNA.
DR   SMR; O52550; 18-441.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:InterPro.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:InterPro.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337; DAHP_synth_2; 1.
DR   Pfam; PF01474; DAHP_synth_2; 2.
PE   4: Predicted;
SQ   SEQUENCE   441 AA;  47253 MW;  515614B87B2F187E CRC64;
     MKRQPDFAAH GRAVDRVLAG RLSAALARPA AQQPGWPDAE RAAEVIELLH DAEPIVAPEE
     TARLRARLAS VARGEAFLLQ GGDCAETFAG NTEPHLRANL GVLARMGEVL AEAAGLPVVK
     IARMAGQFAK PRSRTVDALG LPVYRGDIVN SPECTVAART PDPHRMLLAY AHAAGAMDLV
     RKLCAEGLEE PLAAQVVLAG ARRASSPGGR PFPDFGRPPR PAEIYVSHEM LLLDYERAVL
     RTDSSGPEPR LSSGLAHFLW IGERPASSTA PTSTFAELLS NPIGLKLGPS CTPEEVVEYV
     RRLDPHRTPG RLTLVSRMGH AQVRELLPPI VEKVAASGHE VIWQCDPMHG NTRTSGNGYK
     TRHFGHVVAE LAGFFAVHRQ LGTHPGGIHV EVTGDDVTEC LGGAAGIAEA DLPDRYLTAC
     DPRLNADQSV ELAFAIAKML R
//