ID   O54225_SACER            Unreviewed;       361 AA.
AC   O54225;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   19-JAN-2010, entry version 43.
DE   SubName: Full=DTDP-4-keto-6-deoxy-hexose 3,4-isomerase;
GN   Name=eryCII;
OS   Saccharopolyspora erythraea (Streptomyces erythraeus).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=1836;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL2338;
RA   Salah-Bey K., Doumith M., Michel J.M., Haydock S., Cortes J.,
RA   Leadlay P.F., Raynal M.C.;
RT   "Targetted gene inactivation for the elucidation of deoxysugar
RT   biosynthesis in the erythromycin producer saccharopolyspora
RT   erythraea.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE.
RX   MEDLINE=91153324; PubMed=1999200;
RX   DOI=10.1111/j.1432-1033.1991.tb15771.x;
RA   Caffrey P., Green B., Packman L.C., Rawlings B.J., Staunton J.,
RA   Leadlay P.F.;
RT   "An acyl-carrier-protein-thioesterase domain from the 6-
RT   deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-
RT   level production, purification and characterisation in Escherichia
RT   coli.";
RL   Eur. J. Biochem. 195:823-830(1991).
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DR   EMBL; Y14332; CAA74711.1; -; Genomic_DNA.
DR   PIR; S14161; S14161.
DR   RefSeq; YP_001102992.1; -.
DR   SMR; O54225; 28-360.
DR   GeneID; 4940586; -.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   InterPro; IPR001128; Cyt_P450.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
PE   4: Predicted;
KW   Isomerase.
SQ   SEQUENCE   361 AA;  38507 MW;  FE6C52955CC966B3 CRC64;
     MTTTDRAGLG RQLQMIRGLH WGYGSNGDPY PMLLCGHDDD PQRRYRSMRE SGVRRSRTET
     WVVADHATAR QVLDDPAFTR ATGRTPEWMR AAGAPPAEWA QPFRDVHAAS WEGEVPDVGE
     LAESFAGLLP GAGARLDLVG DFAWQVPVQG MTAVLGAAGV LRGAAWDARV SLDAQLSPQQ
     LAVTEAAVAA LPADPALRAL FAGAEMTANT VVDAVLAVSA EPGLAERIAD DPAAAQRTVA
     EVLRLHPALH LERRTATAEV RLGEHVIGEG EEVVVVVAAA NRDPEVFAEP DRLDVDRPDA
     DRALSAHRGH PGRLEELVTA LATAALRAAA KALPGLTPSG PVVRRRRSPV LRGTNRCPVE
     L
//

ID   O33934_SACER            Unreviewed;       360 AA.
AC   O33934;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   19-JAN-2010, entry version 42.
DE   SubName: Full=EryCII;
GN   Name=eryCII;
OS   Saccharopolyspora erythraea (Streptomyces erythraeus).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=1836;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL 2338;
RX   MEDLINE=98015410; PubMed=9353926;
RA   Summers R.G., Donadio S., Staver M.J., Wendt-Pienkowski E.,
RA   Hutchinson C.R., Katz L.;
RT   "Sequencing and mutagenesis of genes from the erythromycin
RT   biosynthetic gene cluster of Saccharopolyspora erythraea that are
RT   involved in L-mycarose and D-desosamine production.";
RL   Microbiology 143:0-0(0).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL 2338;
RA   Summers R.G., Staver M.J., Donadio S., Wendt-Pienkowski E.,
RA   Hutchinson C.R., Katz L.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE.
RX   MEDLINE=91153324; PubMed=1999200;
RX   DOI=10.1111/j.1432-1033.1991.tb15771.x;
RA   Caffrey P., Green B., Packman L.C., Rawlings B.J., Staunton J.,
RA   Leadlay P.F.;
RT   "An acyl-carrier-protein-thioesterase domain from the 6-
RT   deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-
RT   level production, purification and characterisation in Escherichia
RT   coli.";
RL   Eur. J. Biochem. 195:823-830(1991).
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DR   EMBL; U77454; AAB84066.1; -; Genomic_DNA.
DR   PIR; S14161; S14161.
DR   SMR; O33934; 28-359.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   InterPro; IPR001128; Cyt_P450.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
PE   4: Predicted;
SQ   SEQUENCE   360 AA;  38420 MW;  1BBA2AF25C102354 CRC64;
     MTTTDRAGLG RQLQMIRGLH WGYGSNGDPY PMLLCGHDDD PQRRYRSMRE SGVRRRTETW
     VVADHATARQ VLDDPAFTRA TGRTPEWMRA AGAPPAEWAQ PFRDVHAASW EGEVPDVGEL
     AESFAGLLPG AGARLDLVGD FAWQVPVQGM TAVLGAAGVL RGAAWDARVS LDAQLSPQQL
     AVTEAAVAAL PADPALRALF AGAEMTANTV VDAVLAVSAE PGLAERIADD PAAAQRTVAE
     VLRLHPALHL ERRTATAEVR LGEHVIGEGE EVVVVVAAAN RDPEVFAEPD RLDVDRPDAD
     RALSAHRGHP GRLEELVTAL ATAALRAAAK ALPGLTPSGP VVRRRRSPVL RGTNRCPVEL
//

ID   P95746_STRFR            Unreviewed;       423 AA.
AC   P95746;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-JUL-1997, sequence version 2.
DT   19-JAN-2010, entry version 46.
DE   SubName: Full=Hypothetical NDP hexose 3,4 isomerase;
GN   Name=tylMIII(orf1*);
OS   Streptomyces fradiae.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1906;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=T59235;
RX   MEDLINE=97183662; PubMed=9031628; DOI=10.1016/S0378-1119(96)00595-1;
RA   Gandecha A.R., Large S.L., Cundliffe E.;
RT   "Analysis of four tylosin biosynthetic genes from the tylLM region of
RT   Streptomyces fradiae.";
RL   Gene 184:197-203(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=T59235;
RA   Gandecha A.R.;
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; X81885; CAA57471.1; -; Genomic_DNA.
DR   SMR; P95746; 46-418.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PRINTS; PR00359; BP450.
PE   4: Predicted;
KW   Heme; Iron; Isomerase; Metal-binding; Monooxygenase; Oxidoreductase.
SQ   SEQUENCE   423 AA;  44149 MW;  771A75D6FFBD8597 CRC64;
     MNTAAGPTGT AAGGTTAPAA AHDLSRAGRR LQLTRAAQWF AGNQGDPYGM ILRAGTADPA
     PYEEEIRERG PLFHSELLGT WVTGSRHVAD AVTADDAFGA LTADGARPGV RELPLSGSAL
     DAAHGNPGGP PLPGGWPHRP PDREERDDPD RHAADLLNAA GPGQVLDLVP FARRLAARTT
     GAWLGVPAER LPRFETALTG CRRALDALLC PQLLADARAG LAAEEALRAV LGETPEARGR
     PPGAVEAARA HAVSAAEPIA VLLCNAVREL MERPAQWRAL TADPGLAGAA ITETLLWAPP
     VRLESRVARE TAVLAGRTLP AGTHLVVLAA AANRDACRNA GPAVTGFDVL RRASDGGPQP
     HGLPEDLHFR LSGPLVRRTA EAGLRALAER FPGLRPAGPA VRVRRSPVLR GLGRLPVAPY
     VPE
//

ID   O87829_STRAT            Unreviewed;       401 AA.
AC   O87829;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   19-JAN-2010, entry version 34.
DE   SubName: Full=Cytochrome P450 monooxygenase;
GN   Name=oleP1;
OS   Streptomyces antibioticus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1890;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 11891;
RX   MEDLINE=98420102; PubMed=9749673; DOI=10.1007/s004380050816;
RA   Olano C., Rodriguez A.M., Michel J.M., Mendez C., Raynal M.C.,
RA   Salas J.A.;
RT   "Analysis of a Streptomyces antibioticus chromosomal region involved
RT   in oleandomycin biosynthesis, which encodes two glycosyltransferases
RT   responsible for glycosylation of the macrolactone ring.";
RL   Mol. Gen. Genet. 259:299-308(1998).
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DR   EMBL; AJ002638; CAA05640.1; -; Genomic_DNA.
DR   SMR; O87829; 39-399.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PRINTS; PR00359; BP450.
PE   4: Predicted;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
SQ   SEQUENCE   401 AA;  42142 MW;  AFA39DBE28302835 CRC64;
     MEDSELGRRL QMLRGMQWVF GANGDPYARL LCGMEDDPSP FYDAIRTLGE LHRSRTGAWV
     TADPGLGGRI LADRKARCPE GSWPVRAKTD GLEQYVLPGH QAFLRLEREE AERLREVAAP
     VLGAAAVDAW RPLIDEVCAG LAKGLPDTFD LVEEYAGLVP VEVLARIWGV PEEDRARFGR
     DCRALAPALD SLLCPQQLAL SKDMASALED LRLLFDGLDA TPRLAGPADG DGTAVAMLTV
     LLCTEPVTTA IGNTVLGLLP GQWPVPCTGR VAAGQVAGQA LHRAVSYRIA TRFAREDLEL
     AGCEVKSGDE VVVLAGAIGR NGPSAAAPPA PPGPAAPPAP SVFGAAAFEN ALAEPLVRAV
     TGAALQALAE GPPRLTAAGP VVRRRRSPVV GGLHRAPVAA A
//

ID   Q9ZGH8_9ACTO            Unreviewed;       402 AA.
AC   Q9ZGH8;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   19-JAN-2010, entry version 42.
DE   SubName: Full=Putative tautomerase;
GN   Name=desVIII;
OS   Streptomyces venezuelae.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=54571;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15439;
RX   MEDLINE=98445333; PubMed=9770448; DOI=10.1073/pnas.95.21.12111;
RA   Xue Y., Zhao L., Liu H.W., Sherman D.H.;
RT   "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces
RT   venezuelae: architecture of metabolic diversity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998).
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DR   EMBL; AF079762; AAC68676.1; -; Genomic_DNA.
DR   SMR; Q9ZGH8; 45-400.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00359; BP450.
PE   4: Predicted;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
SQ   SEQUENCE   402 AA;  41996 MW;  A0EF6967886672A0 CRC64;
     MTDDLTGALT QPPLGRTVRA VADRELGTHL LETRGIHWIH AANGDPYATV LRGQADDPYP
     AYERVRARGA LSFSPTGSWV TADHALAASI LCSTDFGVSG ADGVPVPQQV LSYGEGCPLE
     REQVLPAAGD VPEGGQRAVV EGIHRETLEG LAPDPSASYA FELLGGFVRP AVTAAAAAVL
     GVPADRRADF ADLLERLRPL SDSLLAPQSL RTVRAADGAL AELTALLADS DDSPGALLSA
     LGVTAAVQLT GNAVLALLAH PEQWRELCDR PGLAAAAVEE TLRYDPPVQL DARVVRGETE
     LAGRRLPAGA HVVVLTAATG RDPEVFTDPE RFDLARPDAA AHLALHPAGP YGPVASLVRL
     QAEVALRTLA GRFPGLRQAG DVLRPRRAPV GRGPLSVPVS SS
//