ID   O66069_BACLI            Unreviewed;      3582 AA.
AC   O66069;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   19-JAN-2010, entry version 49.
DE   SubName: Full=Lichenysin synthetase A;
GN   Name=licA;
OS   Bacillus licheniformis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 10716;
RX   MEDLINE=99084949; PubMed=9864322;
RA   Konz D., Doekel S., Marahiel M.A.;
RT   "Molecular and biochemical characterization of the protein template
RT   controlling biosynthesis of the lipopeptide lichenysin.";
RL   J. Bacteriol. 181:133-140(1999).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; U95370; AAD04757.1; -; Genomic_DNA.
DR   HSSP; O30409; 1DNY.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 3.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 3.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine.
SQ   SEQUENCE   3582 AA;  402576 MW;  164E66D1103C1BE1 CRC64;
     MGNTFYPLTH AQRRIWYTEK FYPGTSVSNL SGFGKLKSAS GIDSGLLTEA IRQFVRTNET
     MRFRLMFEGE DEPKQYIAED EPFQIECFDA SESGGADGVL KWGQAEARRP LPLYGSPLFK
     FAVVRISEEE SWFFAKVHHI ISDGISMTIL GNRITDIYLK LAKGETGLEP VQSSFTEHIQ
     SELEYENSKR FQKDKAYWNA QYEVIPEPVS LKSSDTYQIQ LDAARFSKEI SPALYKKIQT
     YCKEHNISVL SLFLSILHIY MHRITGQKDV VLGTFMGNRT NAKEKQMLGM FVLTIPMKAS
     IDVHQDFSAF VQERMKDQLK IIRHQKYPYN LLINDLRERQ PHVSKLFSVS LEYQVMQWQR
     KETLSFLTEP IFSGSEVNDI SIHVKERWDT GTLAIDFDYR EELFTCEELA VLYERLMTLL
     EDALLFPQKT IAELEIVPAF EKERLLKRAS SQTIAYDKNM TLHGLFEQKA ADHPEKTAVV
     YEGQKLSYRE LNEQSNRLAR ALRRRGIGPD APAAVVMERS ERVITAMLGV LKAGGAYVPI
     DPGFPEERIR FMLEDSKVKV VITDSGLTFE TAETVRFSEA LSESLENGHP SSEAGAGHLA
     YIIYTSGTTG RPKGVMIEHR QVHHLVRGLQ QAVGAYDQDD LKLALLAPFH FDASVQQIFT
     SLLLGQTLYI VPKKTVSDGR ALSDYYRRHQ IDVTDGTPAH LQLLSAADDL SGVKLRHMLV
     GGEALSRVAT ERLLQLFAET AESVPDVTNV YGPTETCVDA SSFTMTNHAD LQGDTAYVPI
     GRPIGNNRFY ILDENGALLP DGVEGELYIA GDGVGRGYLN LPDMTADKFL EDPFVPGGFM
     YRTGDAVRWL PDGTVDFIGR KDDQVKIRGY RIELGEIESV LQGAPAVGKA VVLARPETGG
     SLEVCAYVVP KQSGEIHLQG LREHLSKHLP DYMIPSHFVE LDEIPLTGSG KVDRKALLRH
     EVSVSGTAEY AAPRNEYEEK MVGIWQEVLG TEQVGIHDQF FELGGHSLKA MAMLAKIYKA
     FGVEVPLQVL FEKPTVAALS GFVSEAEKDG FTVIEPAPES DDYPLSLAQQ RIYIVSQLED
     AGVGYNMPAA AMLEGTLDVQ RLEAAFQKLI DRHEALRTSF TVVDGEPRQN IHQRVQFKIE
     KVKADGKPIE QMAKSFVRRF DLAKAPLMRA GLVRLADRRH VLLFDMHHLV SDGVSISIIL
     NELAALYKGE ELPEPNLHYK DYAFWQRTHA PKGFQKEEAY WQSVFARELP VLQLITDEPR
     PSVQSFEGDR VSAVLPQDMK EKLAVLAEQN GATLYMVMLA AYNMLLAKYS GQEDVIVGTP
     AAGRRHSDLE GIIGMFVNTL AIRSKVESGR TFRDFLHDVK KTVIDAFEHQ EYPFERLAEK
     VGASRDLSRH PVFDTMFILQ NAWEDIPMLG DLHLSIYETN FNIAKFDLTL QAKEEQGELI
     LDLDYSTKLF KKDTAERMLK AYLHLLEGMT ADPLRRIGEY SLLTEEETNR QLVAFNPAAS
     DYPREKTIVQ LFEEQAAERG GHPALQFEDK VWSYGELNRK ANQLARRLRE RGVQPGTTAA
     ILTARSAEMV IGILAVLKAG AAYVPIDPDH PEKRVQHFFE DSGAAVLLTQ KAMKPLAEAA
     EFGGDILFLE DEHLYLGDAS DLRLPISPEA MANLTYTSGT TGTPKGNMVS HRNILRTVKN
     TNYLDVMTSD IVLSISNYVF DAFMFDVFGS LLNGAKLVIA PKDTILDMSR LAHVLEKEKV
     TVLMITTALF NLLTDMRPDS LKGLRRVLFG GERASVDHVR RALNTVGKGR LLHMYGPSES
     TVFTTYYPVN EVPDDAQAIP IGKPVSNTEV LILDSFGNVQ PAGVAGELCV GGDGLVRGYF
     NRPELTAEKF TEHPFKTGEK IYRTGDMARW LADGCLEFIG RIDHQVKIRG QRIELGEIEH
     HLVTHEMVQE AAVLAVDTGK RDQMICAYFT ADQELSSEEL RRYAAEGLPG YMIPSVFMQL
     QELPLTGNGK VDRRALPEPD VTQAAQKEYT APRSRTGAQL ADLWQEVLNV PKIGVHDNFF
     ELGGHSLIGM TLIARIQQEM NVDLQLKDLF QAPTIETLAQ AAEKTEKKSA VYIEAVPDRD
     TYPVSSAQKR LYVLQQIEGA EKSYHMPAVL QLEGKLDLKR LESAAQMLIK RHEAFRTTFE
     IKDGEPVQRI WEAAELTIDV IDADEQEAEK LIKEFIRPFD LTKAPLFRMS IIRFTGEKHL
     LLVDMHHIIS DGASVSVLID EMTKLYAGEA LEPLRIQYKD FSVWQQHLLT ERHKVQEEYW
     LKELAGELPV LTLPADYPRP SIQTFEGSRL SFALKPELVQ QLRKLAKETD STLYMVLAAS
     YSALLSKLSG QSEVIVGSPA AGRPHTDLNR IIGMFVNTLA IRTRPEGDKP FSAFLEEVKE
     TTLGAFEHQD YPFEELIEKL NIQRDMSRNP LFDAVFSMRN ADLKDLSMEG ITLKPYDFAH
     QTAKFDLTLT AAEEDGLLVF EMEYNTALFK HESIERWRGY WVNLLEAVAE NPDARLSELS
     LLDEAEKRRI VQNWNETRLA VPQDKTVHEL FEAQVLRTPD RGAAVYNGVK WTYKELNARA
     NRLARLLIEK GARPEQRIGI MVKPSLEMAA GVLAILKAGA AYVPIDPSYP AERIGYVLKD
     SGAELLLTQT NLAAPEEFSG ETLLLDSMLS EEITKDDEVN PQAGTQSDNL AYLIYTSGTT
     GQPKGVMVEH RSLVNLCYWH NDAFKVTEQD KSAKYAGFGF DASVWEMFPY WIAGAELHII
     DEAIRMDITR LNQYFEENKI TITFLPTQLC EQFMELDNQS LRVLLTGGDK LKRIAKRSYT
     LVNNYGPTEN TVVATSTAID PDKGMLSIGK PIANTRAYVL GQNNEVQPVG VAGELCIAAR
     GLARGYLNKP EETAKRFTED PFVPGERMYR TGDAVKWLED GRLEYIGRID QQVKIRGFRI
     ELSEIEVQLA RLSEVQEAVV TDIEDACGNK ALCGYVVANE QLDTESLARK LAQTLPDYMV
     PSFWVQLKEL PVTANGKVDR RALPQPDVEA QTAEYKAPLT ETEQLLADIW QEVLGIDRIG
     ITDNFFALGG DSIKGIQMAS RLQQHGWKLE MKDLFQHPTI GELSAYVQAA DDQPIDQNPV
     EGEVTLTPIQ RWFFERRFTN EHHWNQSVML HALTGFDPET AGKALSKLIE HHDALRMVYQ
     RNGDGIVQYN RGLEETAVRP EVIRFNESGA ELEAAVLKAS NRIQSSIDLT EGPLLKAAIF
     KTDQGDHLLI VIHHLVVDGI SWRILLEDFA AGYAQAEKGE PIILQDKTHS FAEYAARLEE
     YAGSKAFAKE IGYWQEIEQA ETAALPKDDE AEDKRMRHTK TAEFSLSKEE TEQLMTKVHE
     AYNTEMNDIL LTALGLALKE WTGQEDFIIC LEGHGREDII DGLNISRTVG WFTSQFPALI
     QMRHSGDIGY QIKQIKEELR HIPNKGIGYG IYRYLTEEGK KAQPIKHDIS FNYLGQFTEM
     ADSGLFTRST LPSGDPLSPE TEKPNALDIV GYIEDGILTM SIAYHSLEYK ESTVAAVAAS
     FKTYLLQLID HCLERDGGEL TPSDLGDDEL TLEELDKLME IF
//