ID   O69211_ACTPA            Unreviewed;       342 AA.
AC   O69211;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   19-JAN-2010, entry version 35.
DE   SubName: Full=Aminodehydroquinate synthase;
OS   Actinosynnema pretiosum subsp. auranticum.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Actinosynnemataceae; Actinosynnema.
OX   NCBI_TaxID=42198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC31565;
RA   Kim C.G., Kirschning A., Bergon P., Ahn Y., Wang J.J., Shibuya M.,
RA   Floss H.G.;
RT   "Formation of 3-amino-5-hydroxy-benzoic acid, the precursor of mC7N
RT   units in ansamycin antibiotics, by a new variant of the shikimate
RT   pathway.";
RL   J. Am. Chem. Soc. 114:4941-4943(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC31565;
RX   MEDLINE=98174059; PubMed=9512878; DOI=10.1016/S1074-5521(98)90141-7;
RA   August P.R., Tang L., Yoon Y.J., Ning S., Muller R., Yu T.W.,
RA   Taylor M., Hoffmann D., Kim C.G., Zhang X., Hutchinson C.R.,
RA   Floss H.G.;
RT   "Biosynthesis of the ansamycin antibiotic rifamycin: deductions from
RT   the molecular analysis of the rif biosynthetic gene cluster of
RT   Amycolatopsis mediterranei S699.";
RL   Chem. Biol. 5:69-79(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC31565;
RX   MEDLINE=98165773; PubMed=9497318; DOI=10.1074/jbc.273.11.6030;
RA   Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G.;
RT   "3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the
RT   formation of the precursor of mC7N units in rifamycin and related
RT   antibiotics.";
RL   J. Biol. Chem. 273:6030-6040(1998).
CC   -!- COFACTOR: NAD (By similarity).
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DR   EMBL; U33059; AAC14006.1; -; Genomic_DNA.
DR   HSSP; P07547; 1DQS.
DR   SMR; O69211; 14-335.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:InterPro.
DR   HAMAP; MF_00110; DHQ_synthase; 1; -.
DR   InterPro; IPR016303; DHQ_synth.
DR   InterPro; IPR002658; DHQ_synth_AroB.
DR   InterPro; IPR016037; DHQ_synth_AroB_sub.
DR   PANTHER; PTHR21090:SF1; DHQ_synth_AroB; 1.
DR   Pfam; PF01761; DHQ_synthase; 1.
DR   PIRSF; PIRSF001455; DHQ_synth; 1.
PE   3: Inferred from homology;
KW   Lyase; NAD.
SQ   SEQUENCE   342 AA;  35746 MW;  C98D335FFDD33F51 CRC64;
     MPTTATTREV RVELGERAYT VHIGHGVRAA LPDVVRALGA RRAVVVTARP PDQTPDPGVP
     SLVLPARDGE HDKTLATVAH LCSRFAEFGL TRADVVVSCG GGTTTDAVGL AASLYHRGTP
     VVHVPTSLLA QVDASVGGKT AVNLPEGKNL VGSYWQPAAV LCDLDLLATL PERELRNGLG
     EIARCHFIGA PGLDRLPLLD QVAASVALKA RVVAADERDR GLRHTLNYGH TLGHALELAT
     GFAVRHGEGV AIGTVFAGRL AGALGRIGPD RVAEHHAVVA GYGLPVALPP GVPDDELLRF
     VRRDKKSTGG LAFVLDGPRG AELVRDVDEH VVAATLAAMP RA
//